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CAS RN: 111974-72-2 | Product Number: Q0092

Quetiapine Hemifumarate

Chemical Structure of Quetiapine Hemifumarate

Purity: >98.0%(T)(HPLC)
Synonyms:
Product Documents:
5G
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Product Number Q0092
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__2__1H__2__5N__3O__2S·^^1/__2C__4H__4O__4 = 441.55 
Physical State (20 deg.C) Solid
Storage Temperature Room Temperature (Recommended in a cool and dark place, <15°C)
CAS RN 111974-72-2
Related CAS RN 111974-69-7
Reaxys Registry Number 8378094
PubChem Substance ID 160871365
Merck Index (14) 8039
MDL Number

MFCD03423782

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %
Purity(Neutralization titration) min. 98.0 %
Melting point 172.0 to 176.0 °C
Properties (reference)
Melting Point 174 °C
Solubility (soluble in) Dimethylformamide
Solubility (slightly sol. in) Methanol
Solubility (insoluble in) Ether
GHS
Pictogram Pictogram Pictogram
Signal Word Danger
Hazard Statements H302 : Harmful if swallowed.
H370 : Causes damage to organs.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P260 : Do not breathe dust.
P270 : Do not eat, drink or smoke when using this product.
P264 : Wash skin thoroughly after handling.
P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor.
P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth.
P405 : Store locked up.
Related Laws:
RTECS# KK3605000
Transport Information:
Application
Quetiapine Hemifumarate: A Multi-Acting Receptor Targeted Antipsychotic (MARTA)

Quetiapine hemifumarate is known as a multi-acting receptor targeted antipsychotic (MARTA), such as clozapine [C2547] and olanzapine [O0393]. Quetiapine has greater affinity for serotonin 5-HT2A and dopamine D1 and D2 receptors. Furthemore, quetiapine has various affinities for multiple receptors, including 5-HT1A and α1- and α2-adrenergic receptors. While, quetiapine binds weakly to benzodiazepine (BZD) and muscarinergic M1A receptors. The precise mechanism of action is unknown, but quetiapine is used as a thienobenzodiazepine atypical antipsychotic. (The product is for research purpose only.)

References


PubMed Literature


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