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CAS RN: 106308-44-5 | Product Number: R0143

Rufinamide


Purity: >98.0%(HPLC)
Synonyms:
  • 1-(2,6-Difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide
Documents:
25MG
₹2,300
1   ≥20 
100MG
₹5,700
1   17  
1G
₹14,500
Contact Us 12  

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Product Number R0143
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__1__0H__8F__2N__4O = 238.20  
Physical State (20 deg.C) Solid
CAS RN 106308-44-5
Reaxys Registry Number 13495800
PubChem Substance ID 253662493
Merck Index (14) 8293
MDL Number

MFCD00865314

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Elemental analysis(Nitrogen) 22.50 to 24.50 %
Melting point 239.0 to 243.0 °C
Properties (reference)
Melting Point 241 °C
Solubility in water Insoluble
Solubility (very slightly) Methanol,Tetrahydrofuran
Solubility (insoluble in) Ethanol
GHS
Pictogram Pictogram
Signal Word Warning
Hazard Statements H336 : May cause drowsiness or dizziness.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray.
P271 : Use only outdoors or in a well-ventilated area.
P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell.
P403 + P233 : Store in a well-ventilated place. Keep container tightly closed.
P405 : Store locked up.
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Transport Information:
Application
Rufinamide: A Broad-Spectrum Anticonvulsant Agent

Rufinamide is an antiepileptic agent with a triazole derivative structure. It is showed broad-spectrum anticonvulsant properties at nontoxic doses in animal models. The principal mechanism of action of rufinamide is considered to be the modulation of the activity of sodium channels and, in particular, prolongation of the inactive state of the channel. Rufinamide is extensively metabolized in the liver by non-CYP450 enzymes. Recently, rufinamide is in development for the adjunctive treatment of refractory epilepsy, Lennox-Gastaut syndrome (LGS). (The product is for research purpose only.)

References


PubMed Literature


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