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CAS RN: 106308-44-5 | Product Number: R0143
Rufinamide
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Purity: >98.0%(HPLC)
Synonyms:
- 1-(2,6-Difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide
Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 25MG |
₹2,300
|
1 | ≥20 |
|
| 100MG |
₹5,700
|
1 | 17 |
|
| 1G |
₹14,500
|
Contact Us | 12 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 22.50 to 24.50 % |
| Melting point | 239.0 to 243.0 °C |
Properties (reference)
| Melting Point | 241 °C |
| Solubility in water | Insoluble |
| Solubility (very slightly) | Methanol,Tetrahydrofuran |
| Solubility (insoluble in) | Ethanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H336 : May cause drowsiness or dizziness. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P271 : Use only outdoors or in a well-ventilated area. P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. P405 : Store locked up. |
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Application
Rufinamide: A Broad-Spectrum Anticonvulsant Agent
Rufinamide is an antiepileptic agent with a triazole derivative structure. It is showed broad-spectrum anticonvulsant properties at nontoxic doses in animal models. The principal mechanism of action of rufinamide is considered to be the modulation of the activity of sodium channels and, in particular, prolongation of the inactive state of the channel. Rufinamide is extensively metabolized in the liver by non-CYP450 enzymes. Recently, rufinamide is in development for the adjunctive treatment of refractory epilepsy, Lennox-Gastaut syndrome (LGS). (The product is for research purpose only.)
References
- Rufinamide (a review)
- Rufinamide: a new anti-epileptic medication (a review)
- Rufinamide for generalized seizures associated with Lennox-Gastaut syndrome (a review)
- Third-generation antiepileptic drugs: mechanisms of action, pharmacokinetics and interactions (a review)
- Simultaneous HPLC-UV analysis of rufinamide, zonisamide, lamotrigine, oxcarbazepine monohydroxy derivative and felbamate in deproteinized plasma of patients with epilepsy
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