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CAS RN: 321-64-2 | Product Number: T3994

Tacrine


Purity: >98.0%(T)(HPLC)
Synonyms:
  • 1,2,3,4-Tetrahydroacridin-9-amine
  • 1,2,3,4-Tetrahydro-9-acridinamine
  • 9-Amino-1,2,3,4-tetrahydroacridine
  • THA
Documents:
250MG
₹4,200.00
Contact Us 4  
1G
₹12,500.00
2   7  

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Product Number T3994
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__1__3H__1__4N__2 = 198.27 
Physical State (20 deg.C) Solid
Storage Temperature Room Temperature (Recommended in a cool and dark place, <15°C)
Store Under Inert Gas Store under inert gas
Condition to Avoid Air Sensitive
CAS RN 321-64-2
Reaxys Registry Number 147610
PubChem Substance ID 468593059
MDL Number

MFCD00046923

Specifications
Appearance White to Light yellow powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %
Melting point 181.0 to 185.0 °C
NMR confirm to structure
Properties (reference)
Melting Point 183 °C
Maximum Absorption Wavelength 325(EtOH) nm
GHS
Pictogram Pictogram
Signal Word Danger
Hazard Statements H301 : Toxic if swallowed.
H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P270 : Do not eat, drink or smoke when using this product.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ eye protection/ face protection.
P302 + P352 : IF ON SKIN: Wash with plenty of water.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P362 + P364 : Take off contaminated clothing and wash it before reuse.
P332 + P313 : If skin irritation occurs: Get medical advice/ attention.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
P405 : Store locked up.
Related Laws:
RTECS# AR9532100
Transport Information:
UN Number UN2811
Class 6.1
Packing Group III
Application
Mitochondria research

References


Application
Tacrine: A Reversible Cholinesterase Inhibitor

Tacrine is a reversible cholinesterase inhibitor, and the first approved agent for the treatment of Alzheimer's disease.1) The mechanism of action of tacrine is thought to inhibit the metabolism of acetylcholine and therefore extending its activity and raising levels in the cerebral cortex.2,3) However, since tacrine shows various side effects and toxicity, the development of the next generation inhibitors such as donepezil [D4099 (HCl salt)] is underway.3,4) (The product is for research purpose only.)

References

Documents (Note: Some products will not have analytical charts available.)
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