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CAS RN: 83105-70-8 | Product Number: U0097

Sultamicillin Tosylate Dihydrate


Purity: >98.0%(GC)(T)
Synonyms:
  • Sultamicillin Tosilate Dihydrate
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Product Number U0097
Purity / Analysis Method >98.0%(GC)(T)
Molecular Formula / Molecular Weight C__2__5H__3__0N__4O__9S__2·C__7H__8O__3S·2H__2O = 802.88  
Physical State (20 deg.C) Solid
Storage Temperature 0-10°C
Condition to Avoid Heat Sensitive
CAS RN 83105-70-8
Related CAS RN 76497-13-7
Reaxys Registry Number 25499733
PubChem Substance ID 354335315
Merck Index (14) 8992
MDL Number

MFCD01682151

Specifications
Appearance White to Light yellow powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(with Total Nitrogen) min. 98.0 %(calcd.on anh.substance)
Specific rotation [a]20/D +168 to +186 deg(C=0.5, water/CH3CN 3:2)
Properties (reference)
Specific Rotation 177° (C=0.5,H2O/HcN=3:2)
Solubility in water Insoluble
Solubility (soluble in) Ethanol,Methanol
GHS
Related Laws:
RTECS# XH8460000
Transport Information:
Application
Sultamicillin Tosylate: The Mutual Prodrug of Ampicillin and Sulbactam

Sultamicillin tosylate is a double ester mutual prodrug in which ampicillin [A2092] and the β-lactamase inhibitor sulbactam [S0868] are linked via a methylene group. Sultamicillin is readily absorbed and hydrolyzed by enzymes in the intestinal wall, releasing ampicillin and sulbactam. Ampicillin is an aminopenicillin which exerts its bactericidal activity by inhibiting transpeptidase, an enzyme responsible for the synthesis of the peptidoglycan layer of the bacterial cell wall. Sulbactam is an irreversible inhibitor of many plasmid-mediated and some chromosomal β-lactamases, produced by resistant bacteria. Therefore, sultamicillin is effective against a wide range of gram-positive and gram-negative bacteria including Staphylococcus aureus and Staphylococcus epidermidis, including penicillin-resistant and some methicillin-resistant strains. (The product is for research purpose only.)

References


PubMed Literature


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