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CAS RN: 153437-55-9 | Product Number: W0021
WHI-P180 Hydrochloride
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Purity: >97.0%(T)(HPLC)
Synonyms:
- 3-[(6,7-Dimethoxy-4-quinazolinyl)amino]phenol Hydrochloride
- 3-[(6,7-Dimethoxyquinazolin-4-yl)amino]phenol Hydrochloride
Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 25MG |
₹13,300.00
|
Contact Us | 19 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | W0021 |
| Purity / Analysis Method | >97.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__6H__1__5N__3O__3·HCl = 333.77 |
| Physical State (20 deg.C) | Solid |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Hygroscopic |
| CAS RN | 153437-55-9 |
| Reaxys Registry Number | 8592187 |
| PubChem Substance ID | 468593126 |
| MDL Number | MFCD09026915 |
Specifications
| Appearance | White to Light gray to Light yellow powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Water | max. 2.0 % |
| NMR | confirm to structure |
Properties (reference)
GHS
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Application
WHI-P180 Hydrochloride: A Multi-Kinase Inhibitor
WHI-P180 (hydrochloride) is a multi-kinase inhibitor. There are reports that it inhibits rearranged during transfection (RET) kinase and kinase insert domain receptor (KDR), respectively.1) It also inhibits epidermal growth factor receptor (EGFR) as well as Janus Kinase 3 (JAK3).2,3) It inhibits IgE/antigen-induced vascular hyper-permeability,4) and cyclin-dependent kinase 2 (CDK2).5) In addition, it binds to tau-tubulin kinase 1 (TTBK1).6) (The product is for research purpose only.)
References
- 1) The discovery of 2-substituted phenol quinazolines as potent RET kinase inhibitors with improved KDR selectivity
- 2) 4-[(3-Bromo-4-hydroxyphenyl)amino]-6,7-dimethoxyquinazolin-1-ium chloride methanol solvate and 4-[(3-hydroxyphenyl)amino]-6,7-dimethoxy-1-quinazolinium chloride
- 3) Treatment of post-bone marrow transplant acute graft-versus-host disease with a rationally designed JAK3 inhibitor
- 4) Pharmacokinetics and biologic activity of the novel mast cell inhibitor, 4-(3'-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline in mice
- 5) Binding mode of the 4-anilinoquinazoline class of protein kinase inhibitor: X-ray crystallographic studies of 4-anilinoquinazolines bound to cyclin-dependent kinase 2 and p38 kinase
- 6) X-ray structural analysis of tau-tubulin kinase 1 and its interactions with small molecular inhibitors
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