Published TCIMAIL newest issue No.199
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NLRP3 Inflammasome Inhibitors
It has been reported that NLR family pyrin domain- containing protein 3 (NLRP3), a pattern recognition receptor, forms a complex called NLRP3 inflammasome in response to irritating metabolites and pathogens, and induces the production of pro-inflammatory cytokines, Interleukin (IL)-1β and IL-18. In recent years, it has become clear that excessive activation of the NLRP3 inflammasome is closely related to the development of various inflammatory diseases. Therefore, inhibitors that suppress the activity of the NLRP3 inflammasome have been attracting attention.
Schematic illustration of the production mechanism of IL-1β/IL-18 by NLRP3 inflammasome
(Cited and modified from the reference 3)
Small Molecule NLRP3 Inflammasome Inhibitors
CB2 Receptor Selective Agonists (The Inhibitory Effect Reported)
Antimicrobial Agents (The Inhibitory Effect Reported)
Crude Medicine Ingredients (The Inhibitory Effect Reported)
References
- 1) NLRP3 inflammasome and its inhibitors: a review
- 2) The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation
- 3) NLRP3 inflammasome and gout arthritis (in Japanese)
| Product Number | M3396 |
| CAS RN | 256373-96-3 |
| Purity / Analysis Method: | >95.0%(HPLC)(qNMR) |
| Product Number | V0176 |
| CAS RN | 273404-37-8 |
| Purity / Analysis Method: | >95.0%(HPLC) |
| Product Number | G0150 |
| CAS RN | 1405-86-3 |
| Purity / Analysis Method: | >75.0%(HPLC) |
Product Number: M3396 |
Purity / Analysis Method:
>95.0%(HPLC)(qNMR)
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