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Published TCIMAIL newest issue No.198

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Published TCIMAIL newest issue No.198

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CAS RN: 89-57-6 | Product Number: A0317

5-Aminosalicylic Acid

Purity: >98.0%(T)

Synonyms:

5-Amino-2-hydroxybenzoic Acid
Mesalamine
Mesalazine
5-ASA

Product Documents:

Size	Unit Price	Belgium	Japan*	Quantity
25G	€23.00	8	≥100
500G	€178.00	1	14

*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).

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General Information plus

Specifications & Properties plus

Specifications

Appearance	White to Gray to Brown powder to crystal
Purity(Neutralization titration)	min. 98.0 %
Solubility in HCl	almost transparency

Properties (reference)

Melting Point

265 °C(dec.)

Safety & Regulations plus

GHS

Pictogram
Signal Word	Warning
Hazard Statements	H315 : Causes skin irritation. H319 : Causes serious eye irritation.
Precautionary Statements	P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention.

Related Laws:

EC Number	201-919-1
RTECS#	VO1400000

Transport Information:

HS Number

2922500090

Applications & Literature plus

Application

5-Aminosalicylic Acid (5-ASA): A Gastrointestinal Anti-Inflammatory Agent

5-Aminosalicylic acid (5-ASA or mesalazine) is used as a gastrointestinal anti-inflammatory agent. Although the mechanism of action remains unknown exactly, 5-ASA has in vitro and in vivo pharmacologic effects that decrease leukotriene production, scavenge for free radicals and inhibit leukocyte chemotaxis et al. For clinical purposes, amylose, ethyl cellulose or pH-dependent polymers coated 5-ASA are developed and used for drug delivery to the intestinal tract. In addition, sulfasalazine [S0580] is a prodrug of 5-ASA. (The product is for research purpose only.)

References

Salicylates for ulcerative colitis - their mode of action (a review)
- S. P. L. Travis, D. P. Jewell, Pharmacol. Ther. 1994, 63, 135.
Action of phenolic derivatives (acetaminophen, salicylate, and 5-aminosalicylate) as inhibitors of membrane lipid peroxidation and as peroxyl radical scavengers
- T. C. P. Dinis, V. M. C. Madeira, L. M. Almeida, Arch. Biochem. Biophys. 1994, 315, 161.
5-Aminosalicylic acid abrogates T-cell proliferation by blocking interleukin-2 production in peripheral blood mononuclear cells
- C. Stevens, M. Lipman, S. Fabry, M. Moscovitch-Lopatin, W. Almawi, S. Keresztes, M. A. Peppercorn, T. B. Strom, J. Pharmacol. Exp. Ther. 1995, 272, 399.
Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator-activated receptor-γ
- C. Rousseaux, B. Lefebvre, L. Dubuquoy, P. Lefebvre, O. Romano, J. Auwerx, D. Metzger, W. Wahli, B. Desvergne, G. C. Naccari, P. Chavatte, A. Farce, P. Bulois, A. Cortot, J. F. Colombel, P. Desreumaux, J. Exp. Med. 2005, 201, 1205.
Cyclooxygenase-2-dependent and -independent inhibition of proliferation of colon cancer cells by 5-aminosalicylic acid
- C. Stolfi, D. Fina, R. Caruso, F. Caprioli, M. Sarra, M. C. Fantini, A. Rizzo, F. Pallone, G. Monteleone, Biochem. Pharmacol. 2008, 75, 668.
High-performance liquid-chromatographic determination of 5-aminosalicylic acid and its metabolites in blood plasma
- M. Nobilis, Z. Vybíralová, K. Sládková, M. Lísa, M. Holčapek, J. Květina, J. Chromatogr. A 2006, 1119, 299.

PubMed Literature

Documents

Immunosuppressants and Immunostimulants for Research and Experimental Use

Lipid Mediator Research Reagents

Anti-Rheumatoid Arthritis Agents for Experimental Use

Immune System, Inflammation, Allergy Research Reagents

Pharmaceutical Ingredients for Research and Experimental Use

MALDI Matrix

Product Articles

Product Documents (Note: Some products will not have analytical charts available.)

Safety Data Sheet (SDS)

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Specifications

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Related Products

5-Aminosalicylic Acid [for Biochemical Research]

Product #	A2291
CAS RN	89-57-6
Purity / Analysis Method:	>98.0%(T)

Product Number	A0317
Purity / Analysis Method	>98.0%(T)
Molecular Formula / Molecular Weight	C__7H__7NO__3 = 153.14
Physical State (20 deg.C)	Solid
Storage Temperature	Room Temperature (Recommended in a cool and dark place, <15°C)
Store Under Inert Gas	Store under inert gas
Condition to Avoid	Light Sensitive,Air Sensitive
CAS RN	89-57-6
Reaxys Registry Number	2090421
PubChem Substance ID	87561970
SDBS (AIST Spectral DB)	3423
Merck Index (14)	5904
MDL Number	MFCD00007877

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CAS RN: 89-57-6 | Product Number: A0317