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CAS RN: 6398-98-7 | Product Number: A3133

Amodiaquine Dihydrochloride Dihydrate

Chemical Structure of Amodiaquine Dihydrochloride Dihydrate
×
× Amodiaquine Dihydrochloride Dihydrate

Purity: >98.0%(T)(HPLC)
Synonyms:
  • 4-[(7-Chloroquinolin-4-yl)amino]-2-[(diethylamino)methyl]phenol Dihydrochloride Dihydrate
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Product Number A3133
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__2__0H__2__2ClN__3O·2HCl·2H__2O = 464.81 
Physical State (20 deg.C) Solid
Storage Temperature Room Temperature (Recommended in a cool and dark place, <15°C)
CAS RN 6398-98-7
Related CAS RN 86-42-0&69-44-3
Reaxys Registry Number 17163077
PubChem Substance ID 354335166
Merck Index (14) 572
MDL Number

MFCD00078857
Specifications
Appearance White to Yellow to Orange powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %
Water 7.0 to 9.0 %
Properties (reference)
Maximum Absorption Wavelength 342 nm (MeOH)
Solubility in water Soluble
Solubility (soluble in) Methanol
Solubility (insoluble in) Alcohol
GHS
Related Laws:
EC Number 200-706-0
Transport Information:
HS Number 2933499090
Application
Amodiaquine Dihydrochloride: A 4-Aminoquinoline Antimalarial Agent

Amodiaquine dihydrochloride is a synthetic 4-aminoquinoline antimalarial agent. Amodiaquine is mainly metabolized hepatically towards its major active metabolite N-desethylamodiaquine, by the cytochrome P450 2C8 (CYP2C8). The mechanism of action of amodiaquine against plasmodium is not yet completely understood, but the most plausible explanation is that the active metabolite penetrate the infected red blood cells and prevent the parasite from polymerizing heme into a malarial metabolite called hemozoin, leading to parasite death. Recently, the antimalarial combination of amodiaquine plus artesunate [A2191] has been extensively studied and good efficacy and tolerability has been reported. (The product is for research purpose only.)

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