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Published TCIMAIL newest issue No.196
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CAS RN: 30414-00-7 | Product Number: H1866
5-(Hydroxymethyl)uridine
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 5-Hydroxymethyluridine
- 1-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-(hydroxymethyl)pyrimidine-2,4(1H,3H)-dione
Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 50MG |
€136.00
|
Contact Us | 21 |
|
| 200MG |
€435.00
|
Contact Us | 12 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | H1866 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__0H__1__4N__2O__7 = 274.23 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive |
| CAS RN | 30414-00-7 |
| Reaxys Registry Number | 38534 |
| MDL Number | MFCD00057401 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 164.0 to 168.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 166 °C |
GHS
Related Laws:
Transport Information:
| HS Number | 2934999090 |
Application
5-(hydroxymethyl)uridine: A Base-Modified Ribonucleoside Used in SMUG1 and Epigenetics Studies
Single-strand-selective monofunctional uracil-DNA glycosylase 1 (SMUG1) is a base excision repair enzyme that not only recognizes and removes uracil and oxidized pyrimidines from DNA, but is also capable of processing modified RNA substrates.1,2) There are reports that SUMG1 contributes to rRNA quality control, in part by regulating the level of 5-(hydroxymethyl)uridine (5hmU) in the cell.1,2) It is also possible that 5-(hydroxymethyl)uridine acts as an epigenetic biomarker.3)
References
- 1) The human base excision repair enzyme SMUG1 directly interacts with DKC1 and contributes to RNA quality control
- 2) RNA metabolism guided by RNA modifications: the role of SMUG1 in rRNA quality control (a review)
- 3) Enigmatic 5-hydroxymethyluracil: Oxidatively modified base, epigenetic mark or both?
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