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Published TCIMAIL newest issue No.198
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CAS RN: 187164-19-8 | Product Number: L0306
Luliconazole
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Purity: >98.0%(HPLC)(N)
Synonyms:
- (2E)-2-[(4R)-4-(2,4-Dichlorophenyl)-1,3-dithiolan-2-ylidene]-2-(1H-imidazol-1-yl)acetonitrile
- NND 502
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 250MG |
€80.00
|
Contact Us | 20 |
|
| 1G |
€208.00
|
1 | ≥100 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | L0306 |
| Purity / Analysis Method | >98.0%(HPLC)(N) |
| Molecular Formula / Molecular Weight | C__1__4H__9Cl__2N__3S__2 = 354.27 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Condition to Avoid | Light Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 187164-19-8 |
| Reaxys Registry Number | 8994672 |
| PubChem Substance ID | 468592145 |
| MDL Number | MFCD00953915 |
Specifications
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Melting point | 150.0 to 154.0 °C |
| Specific rotation [a]20/D | -48.0 to -53.0 deg(C=1, DMF) |
Properties (reference)
| Melting Point | 152 °C |
| Specific Rotation | -50° (C=1,DMF) |
| Solubility in water | Insoluble |
| Solubility (soluble in) | Acetone |
| Solubility (slightly sol. in) | Methanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
Transport Information:
| HS Number | 2934999090 |
Application
Lluliconazole: An Optically Active Imidazole Antifungal Agent with Broad-Spectrum Activity
Lluliconazole (NND-502), an optically active imidazole antifungal agent with broad-spectrum activity, appears to inhibit ergosterol synthesis of fungi by inhibiting the enzyme lanosterol 14 α-demethylase. Inhibition of this enzyme’s activity by lluliconazole results in decreased amounts of ergosterol, a constituent of fungal cell membranes. Especially, luliconazole inhibited growth of all filamentous fungi except zygomycetes at low concentration. In addition, luliconazole is the active R enantiomer of a chiral molecule. (The product is for research purpose only.)
References
- In vitro and in vivo antidermatophyte activities of NND-502, a novel optically active imidazole antimycotic agent
- Inhibition of sterol 14 α-demethylation of Candida albicans with NND-502, a novel optically active imidazole antimycotic agent
- Lanoconazole and its related optically active compound NND-502: Novel antifungal imidazoles with a ketene dithioacetal structure (a review)
- In vitro antifungal activities of luliconazole, a new topical imidazole
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