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CAS RN: 24057-28-1 | Product Number: P0942
Pyridinium p-Toluenesulfonate
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Purity: >98.0%(T)
Synonyms:
- PPTS
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 25G |
€28.00
|
17 | ≥60 |
|
|
| 100G |
€75.00
|
6 | 38 |
|
|
| 500G |
€239.00
|
7 | 30 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | P0942 |
Purity / Analysis Method 
|
>98.0%(T) |
| Molecular Formula / Molecular Weight | C__5H__5N·C__7H__8O__3S = 251.30 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Hygroscopic |
| CAS RN | 24057-28-1 |
| Reaxys Registry Number | 3764305 |
| PubChem Substance ID | 87575059 |
| MDL Number | MFCD00013108 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 118.0 to 122.0 °C |
| Solubility in Water | almost transparency |
Properties (reference)
| Melting Point | 120 °C |
| Solubility in water | Soluble |
| Solubility (soluble in) | dichloromethane, Ethanol, Chloroform, Acetone |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H373 : May cause damage to organs through prolonged or repeated exposure. H412 : Harmful to aquatic life with long lasting effects. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P260 : Do not breathe dust. P314 : Get medical advice/ attention if you feel unwell. |
Related Laws:
| EC Number | 246-002-7 |
Transport Information:
| HS Number | 2933310000 |
Application
Application for Introduction of Protecting Groups Using PPTS as an Acid Catalyst
Typical procedure :PPTS catalyzed THP protection of (R)-(+)-glycidol
Pyridinium p-toluenesulfonate (PPTS) (1.00 g, 4.05 mmol) and 3,4-dihydro-2H-pyran (11.3 mL, 121.5 mmol) are added to a stirred solution of (R)-(+)-glycidol (6.00 g, 80.99 mmol) in dichloromethane (80 mL) at 0 °C under argon atmosphere. After 6 h, aqueous NaHCO3 solution (60 mL) is added and the layers are separated. The aqueous layer is extracted with dichloromethane (3x50 mL). Combined organic layer is dried over MgSO4, filtered, and concentrated in vacuo. The crude mixture is purified by column chromatography (EtOAc:hexane = 1:5) to give the desired product (9.22 g, 72%).
Pyridinium p-toluenesulfonate (PPTS) (1.00 g, 4.05 mmol) and 3,4-dihydro-2H-pyran (11.3 mL, 121.5 mmol) are added to a stirred solution of (R)-(+)-glycidol (6.00 g, 80.99 mmol) in dichloromethane (80 mL) at 0 °C under argon atmosphere. After 6 h, aqueous NaHCO3 solution (60 mL) is added and the layers are separated. The aqueous layer is extracted with dichloromethane (3x50 mL). Combined organic layer is dried over MgSO4, filtered, and concentrated in vacuo. The crude mixture is purified by column chromatography (EtOAc:hexane = 1:5) to give the desired product (9.22 g, 72%).
References
- A Facile Synthesis of (S)-Felodipine
Application
PPTS Catalyzed Hydrolysis of Dioxolane-type Acetals
Reference
- Pyridinium Tosylate, A Mild Catalyst for Formation and Cleavage of Dioxolane-type Acetals
PubMed Literature
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