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CAS RN: 341028-37-3 | Product Number: A3166
Alagebrium Chloride
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Purity: >98.0%(HPLC)
Synonyms:
- 4,5-Dimethyl-3-(2-oxo-2-phenylethyl)thiazolium Chloride
Documents:
| Size | Unit Price | Saitama (Kawaguchi) | Hyogo (Amagasaki) | Stock in other WH |
|---|---|---|---|---|
| 200MG |
¥7,800
|
2 | Contact Us | Contact Us |
Available Stock: Prompt shipment (for products) in Saitama/Hyogo warehouse. Stock in other WH: 2-3 Business Days
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* Please contact us if you need further information.
* To send your quote request for bulk quantities, please click on the "Request Bulk Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | A3166 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__3H__1__4ClNOS = 267.77 |
| Physical State (20 deg.C) | Solid |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Hygroscopic |
| CAS RN | 341028-37-3 |
| Related CAS RN | 393121-34-1 |
| Reaxys Registry Number | 11745839 |
| PubChem Substance ID | 354335367 |
| Merck Index (14) | 203 |
| MDL Number | MFCD09027398 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 96.0 % |
Properties (reference)
| Melting Point | 212 °C(dec.) |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
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Application
Alagebrium Chloride: An Advanced Glycation Endproduct (AGE) Crosslink Breaker
Alagebrium chloride (ALT-711) is an advanced glycation endproduct (AGE) crosslink breaker. AGE formation that occurs with aging and diabetes leads to the crosslinking of proteins formed by glycation reaction. The accumulations of AGEs contribute to the pathology events, such as age-related diseases. Alagebrium chloride was the first drug candidate to be clinically tested for the purpose of breaking the crosslinks caused by AGEs, but the development was discontinued. (The product is for research purpose only.)
References
- A Breaker of Advanced Glycation End Products Attenuates Diabetes-Induced Myocardial Structural Changes
- The breakdown of pre-existing advanced glycation end products is associated with reduced renal fibrosis in experimental diabetes
- Therapeutic potential of breakers of advanced glycation end product-protein crosslinks (a review)
- Alagebrium attenuates acute methylglyoxal-induced glucose intolerance in Sprague-Dawley rats
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