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CAS RN: 301836-41-9 | Product Number: B4003
SB 431542
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Purity: >97.0%(HPLC)
Synonyms:
- 4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide
Documents:
| Size | Unit Price | Saitama (Kawaguchi) | Hyogo (Amagasaki) | Stock in other WH |
|---|---|---|---|---|
| 25MG |
¥35,900
|
Contact Us | Contact Us | Contact Us |
| 100MG |
¥98,900
|
1 | 4 | Contact Us |
Available Stock: Prompt shipment (for products) in Saitama/Hyogo warehouse. Stock in other WH: 2-3 Business Days
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
* Please contact us if you need further information.
* To send your quote request for bulk quantities, please click on the "Request Bulk Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | B4003 |
| Purity / Analysis Method | >97.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__2H__1__6N__4O__3 = 384.40 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | <0°C |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 25MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 301836-41-9 |
| Reaxys Registry Number | 9086247 |
| PubChem Substance ID | 468590503 |
| MDL Number | MFCD05865244 |
Specifications
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Water | max. 3.0 % |
Properties (reference)
| Melting Point | 214 °C(dec.) |
GHS
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Application
SB-431542: A Selective Inhibitor TGF-β Type I Receptor Kinase
SB-431542 is a selective inhibitor (or an antagonist) of the transforming growth factor-β superfamily type I (TGF-β type I) receptor kinase. It has been reported that SB-431542 suppresses the proliferation of tumor cells, and evaluates the differential ability of ES and iPS cells.
References
- SB-431542 is a potent and specific inhibitor of transforming growth factor-β superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7
- Inhibition of transforming growth factor (TGF)-β1-induced extracellular matrix with a novel inhibitor of the TGF-β type i receptor kinase activity: SB-431542
- Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling
- Escape from Pluripotency via Inhibition of TGF-β/BMP and Activation of Wnt Signaling Accelerates Differentiation and Aging in hPSC Progeny Cells
- 3つの小分子化合物を用いてヒトiPS細胞の分化能力を促進する基盤技術を開発
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