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CAS RN: 93479-97-1 | Product Number: G0395

Glimepiride


Purity: >98.0%(T)(HPLC)
Synonyms:
Documents:
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Product Number G0395
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__2__4H__3__4N__4O__5S = 490.62  
Physical State (20 deg.C) Solid
CAS RN 93479-97-1
Reaxys Registry Number 7731873
PubChem Substance ID 160870906
Merck Index (14) 4440
MDL Number

MFCD00878417

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Neutralization titration) min. 98.0 %
Melting point 202.0 to 206.0 °C
Properties (reference)
Melting Point 204 °C
Solubility in water Insoluble
Solubility (soluble in) Dimethylformamide
Solubility (very slightly) dichloromethane
Solubility (insoluble in) Methanol,Ethanol
GHS
Pictogram Pictogram
Signal Word Warning
Hazard Statements H361 : Suspected of damaging fertility or the unborn child.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P202 : Do not handle until all safety precautions have been read and understood.
P201 : Obtain special instructions before use.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
P405 : Store locked up.
Related Laws:
RTECS# UX9363950
Transport Information:
Application
Glimepiride: A Sulfonylurea ATP-Dependent K+ Channel Antagonist

Glimepiride (or glimperide) belongs to sulfonylurea antidiabetics which increase the release of insulin from pancreatic B-cells. Sulfonylurea antidiabetics inhibit ATP-gated K+ channels and thereby cause depolarization of the B-cell membrane. The depolarization leads to activation of voltage-dependent Ca channels and Ca2+ influx into the B-cell, and eventually increases insulin release. In addition, extrapancreatic effects may also play a role in the activity of glimepiride. Glimepiride can stimulate glucose transport and lead to increased sensitivity of peripheral tissues to insulin. (The product is for research purpose only.)

References


Application
Pharmacology Studies

References


PubMed Literature


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