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CAS RN: 93479-97-1 | Product Number: G0395
Glimepiride
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Purity: >98.0%(T)(HPLC)
Synonyms:
Documents:
| Size | Unit Price | Saitama (Kawaguchi) | Hyogo (Amagasaki) | Stock in other WH |
|---|---|---|---|---|
| 1G |
¥7,600
|
≥20 | Contact Us | Contact Us |
| 5G |
¥23,000
|
7 | ≥20 | Contact Us |
Available Stock: Prompt shipment (for products) in Saitama/Hyogo warehouse. Stock in other WH: 2-3 Business Days
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* Please contact us if you need further information.
* To send your quote request for bulk quantities, please click on the "Request Bulk Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 202.0 to 206.0 °C |
Properties (reference)
| Melting Point | 204 °C |
| Solubility in water | Insoluble |
| Solubility (soluble in) | Dimethylformamide |
| Solubility (very slightly) | dichloromethane |
| Solubility (insoluble in) | Methanol,Ethanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H361 : Suspected of damaging fertility or the unborn child. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
Related Laws:
| RTECS# | UX9363950 |
Transport Information:
Application
Glimepiride: A Sulfonylurea ATP-Dependent K+ Channel Antagonist
Glimepiride (or glimperide) belongs to sulfonylurea antidiabetics which increase the release of insulin from pancreatic B-cells. Sulfonylurea antidiabetics inhibit ATP-gated K+ channels and thereby cause depolarization of the B-cell membrane. The depolarization leads to activation of voltage-dependent Ca channels and Ca2+ influx into the B-cell, and eventually increases insulin release. In addition, extrapancreatic effects may also play a role in the activity of glimepiride. Glimepiride can stimulate glucose transport and lead to increased sensitivity of peripheral tissues to insulin. (The product is for research purpose only.)
References
- Special pharmacology of the new sulfonylurea glimepiride
- The sulfonylurea drug, glimepiride, stimulates glucose transport, glucose transporter translocation, and dephosphorylation in insulin-resistant rat adipocytes in vitro
- Stimulation of glucose utilization in 3T3 adipocytes and rat diaphragm in vitro by the sulphonylureas, glimepiride and glibenclamide, is correlated with modulations of the cAMP regulatory cascade
- Glimepiride: a review of its use in the management of type 2 diabetes mellitus
- Sulfonylurea stimulation of insulin secretion (a review)
- The development and validation of liquid chromatography method for the simultaneous determination of metformin and glipizide, gliclazide, glibenclamide, or glimperide in plasma
Application
Pharmacology Studies
References
- Glyburide and glimepiride pharmacokinetics in subjects with different CYP2C9 genotypes
- Simultaneous determination of the sulfonylurea glimepiride and its metabolites in human serum and urine by high-performance liquid chromatography after pre-column derivatization
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TCIMAIL
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