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CAS RN: 61825-94-3 | Product Number: O0372

Oxaliplatin


Purity:
Synonyms:
  • (trans-1,2-Cyclohexanediamine)oxalatoplatinum(II)
Documents:
100MG
¥22,600
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Product Number O0372
Molecular Formula / Molecular Weight C__8H__1__4N__2O__4Pt = 397.29  
Physical State (20 deg.C) Solid
Storage Temperature 0-10°C
Store Under Inert Gas Store under inert gas
Condition to Avoid Moisture Sensitive,Heat Sensitive
CAS RN 61825-94-3
Reaxys Registry Number 14621501
PubChem Substance ID 125309438
Merck Index (14) 6912
MDL Number

MFCD00866327

Specifications
Appearance White to Almost white powder to crystal
Elemental analysis(Nitrogen) 6.70 to 7.40 %
Properties (reference)
Solubility in water Practically insoluble
GHS
Pictogram Pictogram
Signal Word Danger
Hazard Statements H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
H317 : May cause an allergic skin reaction.
H334 : May cause allergy or asthma symptoms or breathing difficulties if inhaled.
H341 : Suspected of causing genetic defects.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray.
P272 : Contaminated work clothing should not be allowed out of the workplace.
P202 : Do not handle until all safety precautions have been read and understood.
P201 : Obtain special instructions before use.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P284 : Wear respiratory protection.
P302 + P352 : IF ON SKIN: Wash with plenty of water.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P362 + P364 : Take off contaminated clothing and wash it before reuse.
P304 + P340 : IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention.
P405 : Store locked up.
Related Laws:
ISHL Mutagens
RTECS# TP2275850
Transport Information:
Application
Platinum Coordination Complexes as Antitumor Agents

O0372

The development of platinum coordination complexes as antitumor agents began in the 1960s, and the highest antitumor activity was exhibited by cisplatin [D3371], approved by FDA in 1978. Improved versions carboplatin [C2043] and oxaliplatin were developed to avoid the serious side effects and the problem with resistance associated with the use of cisplatin.1-5)
The platinum complexes diffuse to the tumor cell, where they undergo hydrolysis displacement of their one chloride or carboxylate group leading to a platinum cation. The resulting cation coordinates to the guanine N7-position of DNA give a coordination cation. Then, intrastrand cross-linking occurs to anther guanine via further hydrolysis displacement of the remaining chloride or carboxylate. The forming [Pt(NH2R)2]2+ ― DNA complex distort the DNA helix (Fig. 1 and 2)6). Thus, DNA duplication is hindered, which ultimately triggers tumor cell apoptosis.3)

References


Application
Reagent for pain model

References


Application
Pharmacology study

References


PubMed Literature


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