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CAS RN: 132539-06-1 | Product Number: O0393

Olanzapine


Purity: >98.0%(GC)(T)
Synonyms:
  • 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine
Documents:
1G
¥9,100
≥20  13   ≥20 
5G
¥31,100
6   17   ≥20 
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Product Number O0393
Purity / Analysis Method >98.0%(GC)(T)
Molecular Formula / Molecular Weight C__1__7H__2__0N__4S = 312.44  
Physical State (20 deg.C) Solid
Storage Temperature 0-10°C
Condition to Avoid Heat Sensitive
CAS RN 132539-06-1
Reaxys Registry Number 7655141
PubChem Substance ID 160871343
Merck Index (14) 6822
MDL Number

MFCD00866702

Specifications
Appearance Light yellow to Amber to Dark green powder to crystal
Purity(GC) min. 98.0 %
Purity(Nonaqueous Titration) min. 98.0 %
Properties (reference)
Melting Point 194 °C(dec.)
Solubility in water Insoluble
GHS
Pictogram Pictogram
Signal Word Danger
Hazard Statements H301 : Toxic if swallowed.
H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
H413 : May cause long lasting harmful effects to aquatic life.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P273 : Avoid release to the environment.
P270 : Do not eat, drink or smoke when using this product.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ eye protection/ face protection.
P302 + P352 : IF ON SKIN: Wash with plenty of water.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P362 + P364 : Take off contaminated clothing and wash it before reuse.
P332 + P313 : If skin irritation occurs: Get medical advice/ attention.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
P405 : Store locked up.
Related Laws:
RTECS# XJ9007750
Transport Information:
UN Number UN2811
Class 6.1
Packing Group III
Application
多受容体作用抗精神病薬 (MARTA),オランザピン

Olanzapine is known as a multi-acting receptor targeted antipsychotic (MARTA), such as clozapine [C2547] and quetiapine [Q0092]. Olanzapine has greater affinity for serotonin 5-HT2A and dopamine D2 receptors. Furthermore, olanzapine has various affinities for multiple receptors, including serotonin 5-HT2C, 5-HT6 receptors, dopamine D1-4, histamine H1, and adrenergic α1 receptors. In addition, olanzapine has moderate affinity binding for serotonin 5HT3 and muscarinic M1-5. While, olanzapine binds weakly to GABAA, benzodiazepine (BZD), and β-adrenergic receptors. The precise mechanism of action is unknown, but olanzapine is used as a thienobenzodiazepine atypical antipsychotic.
Recently, it is reported that the use of olanzapine combined with a 5-HT3 receptor antagonist, a neurokinin1 (NK1) receptor antagonist and dexamethasone [D1961] has improved the control of acute chemotherapy-induced nausea and vomiting. (The product is for research purpose only.)

References


PubMed Literature


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