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CAS RN: 127-69-5 | Product Number: U0098

Sulfisoxazole


Purity: >98.0%(HPLC)
Synonyms:
  • 4-Amino-N-(3,4-dimethyl-5-isoxazolyl)benzenesulfonamide
  • Sulfafurazole
Documents:
25G
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Product Number U0098
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__1__1H__1__3N__3O__3S = 267.30  
Physical State (20 deg.C) Solid
Storage Temperature 0-10°C
Condition to Avoid Light Sensitive,Heat Sensitive
CAS RN 127-69-5
Reaxys Registry Number 263871
PubChem Substance ID 354335300
Merck Index (14) 8952
MDL Number

MFCD00003150

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Neutralization titration) min. 98.0 %
Melting point 193.0 to 197.0 °C
Properties (reference)
Melting Point 195 °C
Maximum Absorption Wavelength 271(MeOH) nm
Solubility in water Insoluble
Solubility (soluble in) Methanol,Alcohol
GHS
Pictogram Pictogram
Signal Word Warning
Hazard Statements H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
Precautionary Statements P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ eye protection/ face protection.
P302 + P352 : IF ON SKIN: Wash with plenty of water.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P362 + P364 : Take off contaminated clothing and wash it before reuse.
P332 + P313 : If skin irritation occurs: Get medical advice/ attention.
Related Laws:
RTECS# WO9100000
Transport Information:
Application
Sulfisoxazole: A Sulfonamide Antimicrobial

Sulfisoxazole is a sulfonamide antimicrobial which inhibits bacterial synthesis of dihydrofolic acid (DHF) which is needed to make both purines and pyrimidines, are constituents of DNA and RNA. Sulfonamide antimicrobials structurally resemble 4-aminobenzoic acid (PABA)[A0269], a precursor in bacterial DHF synthesis. Therefore, sulfonamide antimicrobials completely inhibit utilization of PABA and synthesis of DHF, and they possess bacteriostatic activity against a broad spectrum of pathogens. Recently, some new antimicrobials bearing sulfisoxazole moiety have been reported.

References


PubMed Literature


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