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CAS RN: 850559-51-2 | Product Number: B6675
BMVC2
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Purity: >95.0%(HPLC)(qNMR)
Synonyms:
- 3,6-Bis-[2-(1-methylpyridinium-2-yl)vinyl]-9H-carbazole Diiodide
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 5MG |
₩354,900
|
12 | ≥60 | It can be shipped in about 2 weeks after ordering | |
| 25MG |
₩1,419,600
|
13 | ≥60 | It can be shipped in about 2 weeks after ordering |
* Please contact our distributor of SEJIN CI Co., Ltd.
if you would like to purchase TCI products. The above prices do not include freight cost, customs charge and other charges to the destination. SEJIN CI Co., Ltd. (Phone: 02-2655-2480 / email:
sales@sejinci.co.kr)
* The storage conditions are subject to change without notice.
* The storage conditions are subject to change without notice.
| Product Number | B6675 |
Purity / Analysis Method 
|
>95.0%(HPLC)(qNMR) |
| Molecular Formula / Molecular Weight | C__2__8H__2__5I__2N__3 = 657.34 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (-20°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Light Sensitive,Air Sensitive,Moisture Sensitive,Heat Sensitive |
| CAS RN | 850559-51-2 |
| Reaxys Registry Number | 12228066 |
| MDL Number | MFCD32671337 |
Specifications
| Appearance | Light yellow to Yellow to Orange powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(qNMR) | min. 95.0 % |
| NMR | confirm to structure |
Properties (reference)
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
Transport Information:
| H.S.code* | 2933.39-000 |
Application
BMVC 2: A G4 Fluorescent Probe with A Higher Binding Preference
Guanine quadruplexes (G4s) are non-Watson-Crick four-stranded nucleic acid structures held together by noncanonical G-G base tetrads. Recent studies indicate their existence in vivo and their involvement in various biological processes.1) BMVC 2 (also known as o-BMVC) is an isomer of BMVC [B6654]. Both BMVC and BMVC 2 are good fluorescent G4 ligands and can be used as fluorescent probes to image endogenous and exogenous G4 in living cells. Since the two para-pyridinium groups in BMVC play an important role in binding to duplex DNA, BMVC 2 with two ortho-pyridinium groups would coordinate more G4-selectivity with a decrease in binding affinity to duplex DNA. In fact, BMVC 2 is reported to be a better G4 fluorescent probe with a higher binding preference compared to BMVC.2,3) (The product is for research use only.)
References
- 1) G-quadruplex interacting small molecules and drugs: from bench toward bedside (a review)
- 2) Fluorescent probe for visualizing guanine-quadruplex DNA by fluorescence lifetime imaging microscopy
- 3) Binding of Small Molecules to G-quadruplex DNA in Cells Revealed by Fluorescence Lifetime Imaging Microscopy of o-BMVC Foci
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