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CAS RN: 88321-09-9 | Product Number: E1337
E-64d [for Biochemical Research]
![Thumbnail of E-64d [for Biochemical Research]](/medias/E1337.jpg?context=bWFzdGVyfHJvb3R8MTMwMDB8aW1hZ2UvanBlZ3xhR0ZpTDJnMVl5ODRPVE0xTURnNU9UWXpNRE00TDBVeE16TTNMbXB3Wnd8ZTI0NGQ2OGY2YzI2MzcwYTBiYmY5ZjM1MTI3ODlmYjAxYmY0ZmE0Y2EwMzRiMjE2ZGExNzA0YmViM2UwNjFhNw "E-64d [for Biochemical Research]")
![Chemical Structure of E-64d [for Biochemical Research]](/medias/E1337.jpg?context=bWFzdGVyfHJvb3R8NDAzNjZ8aW1hZ2UvanBlZ3xhRFUwTDJobFpDODRPVEl4TmpZMk9UUTFNRFUwTDBVeE16TTNMbXB3Wnd8ZmQwZDliNWYyNWRlNjg2MjU5ZjAzZWFiMzdmNTVlMDMyNGZhNzNmMWI3NGJmZDRhZWE1YjQwOGI3N2ZmMmNjNA "E-64d [for Biochemical Research]")
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![E-64d [for Biochemical Research]](/_ui/responsive/theme-tci/images/missing_product_zoom.webp "E-64d [for Biochemical Research]")
Purity: >95.0%(HPLC)
Synonyms:
- Loxistatin
- Ethyl (2S,3S)-3-[[(2S)-4-Methyl-1-[(3-methylbutyl)amino]-1-oxo-2-pentanyl]carbamoyl]-2-oxiranecarboxylate
- (2S,3S)-3-[[(2S)-4-Methyl-1-[(3-methylbutyl)amino]-1-oxo-2-pentanyl]carbamoyl]-2-oxiranecarboxylic Acid Ethyl Ester
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 5MG |
₩205,000
|
10 | 23 | Contact Us | |
| 25MG |
₩690,900
|
22 | 0 | Contact Us |
* Please contact our distributor of SEJIN CI Co., Ltd.
if you would like to purchase TCI products. The above prices do not include freight cost, customs charge and other charges to the destination. SEJIN CI Co., Ltd. (Phone: 02-2655-2480 / email:
sales@sejinci.co.kr)
* The storage conditions are subject to change without notice.
* The storage conditions are subject to change without notice.
| Product Number | E1337 |
Purity / Analysis Method 
|
>95.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__7H__3__0N__2O__5 = 342.44 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (-20°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container
|
25MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 88321-09-9 |
| Reaxys Registry Number | 5354546 |
| PubChem Substance ID | 468591716 |
| MDL Number | MFCD00132883 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Specific rotation [a]20/D | +48.0 to +53.0 deg(C=1, EtOH) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 126 °C |
| Specific Rotation | 49° (C=1,MeOH) |
GHS
Related Laws:
| RTECS# | RR0404300 |
Transport Information:
| H.S.code* | 2924.29-000 |
Application
E-64d: A Potent and Irreversible Cysteine Protease Inhibitor
Cysteine proteases are enzymes containing nucleophilic cysteine thiol that are important in protein degradation pathway. E-64d (loxistatin) is a cell-permeable ethyl ester of E-64c which is a potent and irreversible cysteine protease inhibitor.
References
- In vitro and in vivo inhibition of cysteine proteinases by EST, a new analog of E-64
- Thiol protease-specific inhibitor E-64 arrests human epidermoid carcinoma A431 cells at mitotic metaphase
- Determination of a cysteine protease inhibitor and its ethyl ester in mouse serum and muscle by liquid chromatography-mass spectrometry
- プロテアーゼインヒビターとプロドラッグデザイン
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