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CAS RN: 204005-46-9 | Product Number: E1494
SU 5416

Purity: >98.0%(T)(HPLC)
Synonyms:
- Semaxinib
- 3-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene]indolin-2-one
- 3-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one
Product Documents:
Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
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100MG |
₩379,300
|
30 | 0 | Contact Us |
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* The storage conditions are subject to change without notice.
* The storage conditions are subject to change without notice.
Product Number | E1494 |
Purity / Analysis Method | >98.0%(T)(HPLC) |
Molecular Formula / Molecular Weight | C__1__5H__1__4N__2O = 238.29 |
Physical State (20 deg.C) | Solid |
Storage Temperature | Refrigerated (0-10°C) |
Store Under Inert Gas | Store under inert gas |
Condition to Avoid | Air Sensitive,Heat Sensitive |
Packaging and Container | 100MG-Glass Bottle with Plastic Insert (View image) |
CAS RN | 204005-46-9 |
Reaxys Registry Number | 9491836 |
MDL Number | MFCD09763655 |
Specifications
Appearance | White to Yellow to Orange powder to crystal |
Purity(HPLC) | min. 98.0 area% |
Purity(Volumetric Analysis) | min. 98.0 % |
Melting point | 224.0 to 228.0 °C |
NMR | confirm to structure |
Properties (reference)
Melting Point | 226 °C |
GHS
Related Laws:
RTECS# | NM3298716 |
Transport Information:
H.S.code* | 2933.79-000 |
Application
SU5416: A Selective Inhibitor of VEGF Receptor Tyrosine Kinase, Flk-1/KDR
SU5416 (semaxanib) is a selective inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinase, Flk-1/KDR (fetal liver kinase 1/kinase insert domain- containing receptor), also known as VEGF receptor 2 (VEGFR2).1-4) VEGF plays a fundamental role in mediating tumor angiogenesis and tumor growth. There are reports that SU5416 suppresses tumor growth,1-4) and also results in angioproliferative pulmonary hypertension (PAH) in adult rats.4) (The product is for research purpose only.)
References
- 1) SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types
- 2) Development of SU5416, a selective small molecule inhibitor of VEGF receptor tyrosine kinase activity, as an anti-angiogenesis agent (a review)
- 3) Distribution, metabolism, and excretion of the anti-angiogenic compound SU5416 (a review)
- 4) The Effects of Antiangiogenic Compound SU5416 in a Rat Model of Pulmonary Arterial Hypertension (a review)
Product Documents (Note: Some products will not have analytical charts available.)
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