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CAS RN: 106463-17-6 | Product Number: T2749

Tamsulosin Hydrochloride


Purity: >98.0%(T)(HPLC)
Synonyms:
  • 5-[(R)-2-[2-(2-Ethoxyphenoxy)ethylamino]propyl]]-2-methoxybenzenesulfonamide Hydrochloride
Documents:
100MG
₩ 185,600
13   1  
1G
₩ 854,400
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Product Number T2749
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__2__0H__2__8N__2O__5S·HCl = 444.97  
Physical State (20 deg.C) Solid
CAS RN 106463-17-6
Related CAS RN 106133-20-4
Reaxys Registry Number 6896058
PubChem Substance ID 125307965
SDBS (AIST Spectral DB) 52985
Merck Index (14) 9049
MDL Number

MFCD00922997

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %
Specific rotation [a]20/D -17.5 to -20.5 deg(C=1, H2O)
Properties (reference)
Melting Point 230 °C(dec.)
Specific Rotation -19° (C=1,H2O)
GHS
Pictogram Pictogram
Signal Word Warning
Hazard Statements H302 : Harmful if swallowed.
H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P270 : Do not eat, drink or smoke when using this product.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ eye protection/ face protection.
P302 + P352 : IF ON SKIN: Wash with plenty of water.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P362 + P364 : Take off contaminated clothing and wash it before reuse.
P332 + P313 : If skin irritation occurs: Get medical advice/ attention.
P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth.
Related Laws:
RTECS# DB2430000
Transport Information:
Application
Pharmacology study

References

  • Evaluation of the pharmacological selectivity profile of alpha1 adrenoceptor antagonists at prostatic alpha1 adrenoceptors: binding, functional and in vivo studies
    • B. A. Kenny, A. M. Miller, I. J. R. Williamson, J. O'Connell, D. H. Chalmers, A. M. Naylor, Br. J. Pharmacol. 1996, 118, 871.
  • Pharmacokinetics and plasma protein binding of tamsulosin hydrochloride in rats, dogs, and humans
    • H. Matsushima, H. Kamimura, Y. Soeishi, T. Watanabe, S. Higuchi, M. Tsunoo, Drug Metab. Dispos. 1998, 26, 240.
  • Comparison of two alpha1-adrenoceptor antagonists, naftopidil and tamsulosin hydrochloride, in the treatment of lower urinary tract symptoms with benign prostatic hyperplasia: a randomized crossover study


PubMed Literature


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