Maximum quantity allowed is 999
Please select the quantity
CAS RN: 524-12-9 | Product Number: W0015
Wedelolactone
×
![]()
×
Purity: >98.0%(HPLC)
Synonyms:
- 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one
- 7-Methoxy-5,11,12-trihydroxycoumestan
Documents:
| Size | Unit Price | Same Day | 2-3 Business Days |
|---|---|---|---|
| 1MG |
₩214,400
|
5 | 2 |
| 10MG |
₩972,800
|
10 | 2 |
* Please contact our distributor of SEJIN CI
if you would like to purchase TCI products. The above prices do not include freight cost, customs charge and other charges to the destination.
* SEJIN CI (Phone: 02-2655-2480 / email: sales@sejinci.co.kr)
* SEJIN CI (Phone: 02-2655-2480 / email: sales@sejinci.co.kr)
| Product Number | W0015 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__6H__1__0O__7 = 314.25 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | 0-10°C |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 524-12-9 |
| Reaxys Registry Number | 332398 |
| MDL Number | MFCD07778564 |
Specifications
| Appearance | White to Dark green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
Properties (reference)
| Melting Point | 315 °C |
| Maximum Absorption Wavelength | 350(MeOH) nm |
GHS
Related Laws:
| RTECS# | DF8078630 |
Transport Information:
| H.S.code* | 2932.20-000 |
Application
Wedelolactone: A Selective and Irreversible Kinase Inhibitor with Broad Range of Biological Activities
Wedelolactone is a natural coumestan originally isolated from herbal plants, including Eclipta alba and in Wedelia calendulacea.1) It has been reported that wedelolactone is a selective and irreversible kinase inhibitor with broad range of biological activities. For example, wedelolactone is a direct inhibitor of IKK complex that can suppress lipopolysaccharide(LPS)-induced caspase-11 expression,2) an antidote for snake venom,3,4) an inhibitor of topoisomerase IIα,5) and an inducer of caspase-dependent apoptosis in cancer cells.6) (The product is for research purpose only.)
References
- 1) Coumestans as the main active principles of the liver drugs Eclipta alba and Wedelia calendulacea
- 2) Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK complex
- 3) Neutralization of lethal and myotoxic activities of South American rattlesnake venom by extracts and constituents of the plant Eclipta prostrata (Asteraceae)
- 4) Ability of wedelolactone, heparin, and para-bromophenacyl bromide to antagonize the myotoxic effects of two crotaline venoms and their PLA2 myotoxins
- 5) Inhibition of topoisomerase IIα: Novel function of wedelolactone
- 6) Wedelolactone, a medicinal plant-derived coumestan, induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt
Documents
Safety Data Sheet (SDS)
Please select Language.
The requested SDS is not available.
Please Contact Us for more information.
Specifications
C of A & Other Certificates
Please enter Lot Number
Incorrect Lot Number is entered
Analytical Charts
Please enter Lot Number
Incorrect Lot Number is entered
The requested Analytical Chart is not available.