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CAS RN: 524-12-9 | Product Number: W0015

Wedelolactone


Purity: >98.0%(HPLC)
Synonyms:
  • 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one
  • 7-Methoxy-5,11,12-trihydroxycoumestan
Documents:
1MG
₩214,400
5   2  
10MG
₩972,800
10   2  
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* SEJIN CI (Phone: 02-2655-2480 / email:  sales@sejinci.co.kr)

Product Number W0015
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__1__6H__1__0O__7 = 314.25  
Physical State (20 deg.C) Solid
Storage Temperature 0-10°C
Condition to Avoid Heat Sensitive
CAS RN 524-12-9
Reaxys Registry Number 332398
MDL Number

MFCD07778564

Specifications
Appearance White to Dark green powder to crystal
Purity(HPLC) min. 98.0 area%
Properties (reference)
Melting Point 315 °C
Maximum Absorption Wavelength 350(MeOH) nm
GHS
Related Laws:
RTECS# DF8078630
Transport Information:
H.S.code* 2932.20-000
*This code is applied to the products when TCI exports from Japan and not for import in your country.
Application
Wedelolactone: A Selective and Irreversible Kinase Inhibitor with Broad Range of Biological Activities

Wedelolactone is a natural coumestan originally isolated from herbal plants, including Eclipta alba and in Wedelia calendulacea.1) It has been reported that wedelolactone is a selective and irreversible kinase inhibitor with broad range of biological activities. For example, wedelolactone is a direct inhibitor of IKK complex that can suppress lipopolysaccharide(LPS)-induced caspase-11 expression,2) an antidote for snake venom,3,4) an inhibitor of topoisomerase IIα,5) and an inducer of caspase-dependent apoptosis in cancer cells.6) (The product is for research purpose only.)

References


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