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Antivirals for Research and Experimental Use

Coronaviruses are enveloped viruses with a positive-sense single-stranded RNA genome and a nucleocapsid of helical symmetry.1) Coronaviruses cause respiratory tract infections in humans, with most severe cases triggered by SARS, MERS, and, recently, COVID-19 (while the disease is named COVID-19, the virus that causes it was named SARS-CoV-2).2) The lungs are the organs most affected by COVID-19 because the virus (using a special surface glycoprotein) accesses host cells via the enzyme ACE2, which is most abundant in the type II alveolar cells of the lungs.3) Some of the trends in anti-SARS-CoV-2 agent development include the search for the viral proteases 3CLpro or PLpro inhibitors, viral protein expression inhibitors, viral entry to host cells inhibitors, as well as inhibitors of viral replication.4)

TCI offers many antiviral agents useful for research and experiment. Currently reported mechanisms and target virus types are summarized below. Literature information is also provided on the "Application" tab in the product details page viewable from the link of Product Number.
 
Product Name Target Virus Types Product No.
Mechanisms: Preventing viral RNA release into the host cell nucleus
Amantadine Influenza A virus A2318
Amantadine Hydrochloride Influenza A virus A0588
Rimantadine Hydrochloride Influenza A virus R0070
Mechanisms: RNA synthesis inhibition
Mizoribine Herpesvirus M2399
PSI-6206 Chronic hepatitis C virus (HCV) D4823
T-1105 Influenza virus, RNA viruses H1485
Mechanisms: DNA synthesis inhibition
Acyclovir Herpesvirus (HSV-1, HSV-2) A1915
Brivudine (= BVdU) Herpesvirus (HSV-1) B3404
Cytarabine (= ara-C) Herpesvirus C2035
Famciclovir Herpesvirus, Chronic hepatitis B virus (HBV) F0842
Fialuridine (= FIAU) Chronic hepatitis B virus (HBV) D4200
Ganciclovir Hydrate Human cytomegalovirus G0315
Idoxuridine (= IDU) Herpesvirus I0258
Mizoribine Herpesvirus M2399
Penciclovir Herpesvirus P2164
Trifluorothymidine Herpesvirus T2511
Vidarabine Monohydrate (= ara-A) DNA virus V0098
Valacyclovir Hydrochloride Herpesvirus (HSV-1, HSV-2) V0111
Valganciclovir Hydrochloride Human cytomegalovirus V0158
Mechanisms: Reverse transcriptase inhibition
Abacavir Human immunodeficiency virus (HIV) A2694
Adefovir Dipivoxil Chronic hepatitis B virus (HBV) A2414
Azidothymidine (= AZT) Human immunodeficiency virus (HIV) A2052
2',3'-Dideoxyadenosine (= ddA) Human immunodeficiency virus (HIV) D3065
Didanosine (= ddI) Human immunodeficiency virus (HIV) D3066
Entecavir Monohydrate Chronic hepatitis B virus (HBV) E0899
Efavirenz Human immunodeficiency virus (HIV) E0997
Emtricitabine Human immunodeficiency virus (HIV), Chronic hepatitis B virus (HBV) E1007
Lamivudine (= 3TC) Human immunodeficiency virus (HIV), Chronic hepatitis B virus (HBV) L0217
Nevirapine Human immunodeficiency virus (HIV) N0922
Stavudine (= d4T) Human immunodeficiency virus (HIV) D3580
Tenofovir Human immunodeficiency virus (HIV), Chronic hepatitis B virus (HBV) T3006
Mechanisms: Protease inhibition
Clemizole Hydrochloride Chronic hepatitis C virus (HCV) C3468
Nelfinavir Mesylate Hydrate Human immunodeficiency virus (HIV) N0986
Ritonavir Human immunodeficiency virus (HIV) R0116
Mechanisms: Neuraminidase inhibition
Zanamivir Hydrate Influenza virus Z0023
Mechanisms: HIV-1 entry inhibition
NBD-556 Human immunodeficiency virus (HIV) N1090
Mechanisms: Interfering with the conversion of chemicals to energy
Tizoxanide Various virus T3862
Mechanisms: Immunostimulation
Imiquimod Herpesvirus, Various virus I0747
Inosine Herpesvirus I0037
Inosine Pranobex Herpesvirus, Human immunodeficiency virus (HIV) I1037
Plerixafor Immunodeficiency virus P2678
Resiquimod Herpesvirus, Various virus R0197
Mechanisms: Interferon induction
Tilorone Dihydrochloride Various virus T2836
Mechanisms: Others
1-Docosanol Herpesvirus D0964
Moroxydine Hydrochloride Influenza virus, Various virus M2443
Moronic Acid Herpesvirus, Human immunodeficiency virus (HIV), Epstein-Barr virus (EBV) M2610
Nitazoxanide Influenza virus, Chronic hepatitis B virus (HBV), Chronic hepatitis C virus (HCV), Various virus N1031
Pirodavir Picornavirus P2665
Ribavirin Various virus R0077

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