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Bioactive Small Molecules
Bioactive Small Molecules for Epigenetic Research
The term "epigenetics" was first proposed by Conrad H. Waddington in 1942. Epigenetics is the study of acquired chemical modifications of DNA and nuclear histone proteins that do not alter the DNA sequence but regulate gene expression and other processes that occur during development, cell differentiation, and carcinogenesis. Among others, DNA methylation and histone modification are two well-researched physiological mechanisms of epigenetic change.
Receptor Tyrosine Kinase (RTK) Inhibitors
RTKs (Receptor tyrosine kinases) are transmembrane glycoproteins present on cell surface that activate various kinds of main cell signaling pathways like MAPK pathway and PI3K pathway. They're important molecules in biological phenomenon to control basic cell activities such as proliferation, differentiation, survival and death. Their excess expression and active mutation have been reported in cancer cells. Numerous specific low molecular-weight drugs and antibodies designed to inhibit their activities have been developed.
Non-Receptor Tyrosine Kinase (Non-RTK) Inhibitors
Non-RTKs are cytosolic TK enzymes that doesn't have a transmembrane domein. Non-RTK's activity is regulated by other factors on cell surface or in the cytoplasm and it transmits signals. Human non-RTK family includes ABL, ACK, CSK, FAK, FES, FRK, JAK, SRC, TEC and SYK. Mutations in a gene for non-RTKs (including BCR-ABL) can result in an aberrant activity of this enzyme; pathologically increased activity of non-RTK may be responsible for growth of malignances, the induction of drug-resistance, and formation of metastasis. Non-RTKs are regarded as important targets in development of anti-tumor agents.
Polyamines are organic compounds having at least two amino groups as part of an otherwise aliphatic chain. The amino groups are usually separated by three or four methylene units, such as putrescine and spermine. Cyclen is the typical example of a class of cyclic polyamines. The polyamines are essential molecules in both eukaryotic and prokaryotic cells, and, therefore, have been isolated from all kinds of living organisms, including humans. Especially, the requirement for and the metabolism of polyamines are frequently dysregulated in cancer, and some polyamines can induce diseases caused by neurotoxins.
Antitumor Ingredients (for Research and Experimental Use)
Tumors are groups of abnormal cells that proliferate independently of the body's inherent "building plan". Benign tumors are non-cancerous growths in the body, and do not spread to other parts of the body. When the tumor cells form a lump or overgrowth, it is referred to as a cancerous tumor or cancer. Cancer remains a leading cause of death and is the subject of tremendous research. Anti-tumor, or anti-cancer, agents can slow tumor growth to prolong mammals' lives or improve their quality of life. TCI supports cancer research and development through the production and supply of hundreds of anti-tumor agents. Please see the applications tab on each product page for relevant research details and applications of the products.
We have a wide range of other bioactive small molecules.
- Activin Receptor-like Kinase Inhibitor
- GSK-3 Inhibitor
- Tyrosine Kinase Inhibitors for Cancer Research
- Antitumor Molecular-Targeted Agents