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Anti-Sulfated Glycan Antibodies
Sulfated glycans are commonly found in glycosaminoglycans, and their diverse sulfation patterns are responsible for a wide variety of biological interactions. For example, 6-sulfo LacNAc (slan) and sulfated sialyl-Lewis X have been reported to respectively act as P-selectin ligand and L-selectin ligand in humans and mice during cell adhesion mediated by selectins involved lymphocyte homing.1,2) Here, TCI offers antibody products useful for detecting these carbohydrate ligands.
References
- 1) 6-Sulfo LacNAc, a novel carbohydrate modification of PSGL-1, defines an inflammatory type of human dendritic cells
- 2) Structure of the O-glycans in GlyCAM-1, an endothelial-derived ligand for L-selectin
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