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CAS RN: 136572-09-3 | ์ ํ๋ฒํธ: I0714
Irinotecan Hydrochloride Trihydrate
×
์๋/๋ถ์ ๋ฐฉ๋ฒ: >98.0%(T)(HPLC)
๋์์ด์:
- CPT-11 Trihydrate
์ ํ๋ฌธ์:
| ํฌ์ฅ๋จ์ | ๊ฐ๊ฒฉ | ๋น์ผ์ถ๊ณ | 2-3์ผ ์ด๋ด ์ถ๊ณ | ์ถ๊ฐ๋ก ํ์ํ ๊ฒฝ์ฐ |
์ถํ ์ ๋ณด
|
|---|---|---|---|---|---|
| 100MG |
โฉ501,200
|
4 | ≥40 | ์ฃผ๋ฌธ ํ 2์ฃผ ์ ๋ ์์๋ฉ๋๋ค |
โข๋ณธ ์ ํ์ ์ฌ๊ณ ๋ ์ผ๋ณธ ๋ณธ์ฌ์ ์ฌ๊ณ ์
๋๋ค. ์ฃผ๋ฌธ์, 5์ผ์์ ์คํ์ค๊น์ง ๋์ฐฉ๋ฉ๋๋ค.
โข๋ณธ๊ฑด์ ์๊ฐ๊ฒฉ์ ํ๊ตญ ๋๋ฆฌ์ ์ ์์ ํ๋งค๊ฐ๊ฒฉ์ ๋๋ค.์์ธํ ์ ๋ณด๊ฐ ํ์ํ์๋ฉด ์ฐ๋ฝํด ์ฃผ์ญ์์ค.( SEJIN CI Co., Ltd. (ํ๊ตญ์ด๋๋ฆฌ์ ) ์ ํ : 02-2655-2480 ์ด๋ฉ์ผ : sales@sejinci.co.kr)
โข๋ณด๊ด ์กฐ๊ฑด์ ์๊ณ ์์ด ๋ณ๊ฒฝ ๋ ์ ์์ต๋๋ค. ์ ํ ๋ณด๊ด ์กฐ๊ฑด์ ์ต์ ์๋ฃ๋ ํํ์ด์ง์ ๊ธฐ์ฌ๋์ด ์์ผ๋ ์ํด ๋ถํ๋๋ฆฝ๋๋ค.
โข๋ณธ๊ฑด์ ์๊ฐ๊ฒฉ์ ํ๊ตญ ๋๋ฆฌ์ ์ ์์ ํ๋งค๊ฐ๊ฒฉ์ ๋๋ค.์์ธํ ์ ๋ณด๊ฐ ํ์ํ์๋ฉด ์ฐ๋ฝํด ์ฃผ์ญ์์ค.( SEJIN CI Co., Ltd. (ํ๊ตญ์ด๋๋ฆฌ์ ) ์ ํ : 02-2655-2480 ์ด๋ฉ์ผ : sales@sejinci.co.kr)
โข๋ณด๊ด ์กฐ๊ฑด์ ์๊ณ ์์ด ๋ณ๊ฒฝ ๋ ์ ์์ต๋๋ค. ์ ํ ๋ณด๊ด ์กฐ๊ฑด์ ์ต์ ์๋ฃ๋ ํํ์ด์ง์ ๊ธฐ์ฌ๋์ด ์์ผ๋ ์ํด ๋ถํ๋๋ฆฝ๋๋ค.
| ์ ํ๋ฒํธ | I0714 |
Purity/Analysis Method 
|
>98.0%(T)(HPLC) |
| M.F. / M.W. | C__3__3H__3__8N__4O__6ยทHClยท3H__2O = 677.20 |
| ๋ฌผ๋ฆฌ์ ์ํ (20 โ) | Solid |
| ๋ณด๊ด ์กฐ๊ฑด
|
Refrigerated (0-10ยฐC) |
| ํผํด์ผ ํ ์กฐ๊ฑด | Heat Sensitive |
| ์ฉ๊ธฐ
|
100MG-Glass Bottle with Plastic Insert (์ด๋ฏธ์ง ๋ณด๊ธฐ) |
| CAS RN | 136572-09-3 |
| ๊ด๋ จ CAS RN
|
100286-90-6&97682-44-5 |
| Reaxys-RN | 4838283 |
| PubChem Substance ID | 87560270 |
| Merck Index (14) | 5091 |
| MDL ๋ฒํธ | MFCD01765731 |
๊ท๊ฒฉํ
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Specific rotation [a]20/D | +22.0 to +26.0 deg(C=1, methanol) |
| Water | 7.0 to 10.0 % |
| NMR | confirm to structure |
๋ฌผ์ฑ์น(์ฐธ๊ณ ์น)
| bp | 257 ยฐC |
| ๋น์จ ๊ดํ ํ์ [ฮฑ]D | 24ยฐ (C=1,MeOH) |
| ์ฉํด์ฑ (์ฉํด) | Methanol |
GHS
| ํฝํ ๊ทธ๋จ |
|
| ์ ํธ ์๋ | Danger |
| ์ํ๋ฌผ ๋ฐ ์ ํด ๋ฑ๋ก | H302 : Harmful if swallowed. H372 : Causes damage to organs through prolonged or repeated exposure. |
| ์ฃผ์ ์ฌํญ | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P314 : Get medical advice/ attention if you feel unwell. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
๋ฒ๊ท ์ ๋ณด
| RTECS # | DW1060750 |
์ด์ก ์ ๋ณด
| HS ๋ฒํธ* | 2933.99-000 |
Application
Irinotecan hydrochloride (CPT-11): A Water Soluble Topoisomerase-I Inhibitor with Enhanced Activity
Irinotecan hydrochloride (CPT-11) is a derivative of 7-ethylcamptothecin (SN-22) [E0781] or Camptothecin (CPT) [C1495]. Irinotecan hydrochloride has greater water solubility and enhanced topoisomerase-I inhibitory activity than theirs. Irinotecan, a prodrug, is converted to a biologically active metabolite 7-ethyl-10-hydroxy-camptothecin (SN-38) [E0748] by a carboxylesterase-converting enzyme. Camptotecin and its derivatives interfere with DNA synthesis by inhibiting the enzyme topoisomerase-I. In order to prevent and correct of topological problems caused by the DNA double helix, topoisomerase-I catalyzes the relaxation of negatively supercoiled DNA, the knotting and unknotting DNA and the linking complementary rings of single-stranded DNA into double-stranded rings. Then the inhibition action induces breaks in single strand DNA. Eventually, this leads to double-strand DNA breaks and apoptosis or cell death. (The product is for research purpose only.)
References
- Synthesis and antitumor activity of 20(S)-camptothecin derivatives: carbamate-linked, water-soluble derivatives of 7-ethyl-10-hydroxycamptothecin
- Identification of a new metabolite of CPT-11 (irinotecan): pharmacological properties and activation to SN-38
- Clinical pharmacokinetics and metabolism of irinotecan (CPT-11) (a review)
- UGT1A1*28 polymorphism as a determinant of irinotecan disposition and toxicity
- The camptothecins (a review)
- Pharmacogenetics of irinotecan metabolism and transport: An update
PubMed Literature
๋ฌธ์
์ ํ๊ธฐ์ฌ
์ ํ๋ฌธ์ (๋ถ์ ์ฐจํธ๋ฅผ ์ ๊ณตํ์ง ๋ชปํ ์๋ ์์ผ๋ ์ํด ๋ฐ๋๋๋ค.)
SDS
์ธ์ด๋ฅผ ์ ํํ์ญ์์ค.
์์ฒญํ SDS๋ฅผ ์ฌ์ฉํ ์ ์์ต๋๋ค.
๋ฒ๊ฑฐ๋กญ๊ฒ ํด๋๋ ค ์ฃ์กํ์ง๋ง ์ด ์์ ๋ณด๋ค ๋ฌธ์ ํด์ฃผ์ญ์์ค.
๊ท๊ฒฉํ
์ํ์ฑ์ ์๏ผ ๊ฐ์ข ์ฆ๋ช ์
๋กฏํธ ๋ฒํธ๋ฅผ ์
๋ ฅํ์ญ์์ค.
์๋ชป๋ ๋กํธ ๋ฒํธ๊ฐ ์
๋ ฅ๋์์ต๋๋ค.
์ํ ์ํ์ฑ์ ์
์ํ์ฑ์ ์ ์ํ์ ๋ค์ด๋ก๋ํ ์ ์์ต๋๋ค. ์ํ์ ๋ฐ๋์ ์ต์ ๋กํธ์ ๊ฒฐ๊ณผ๋ฅผ ๋ํ๋ด๋ ๊ฒ์ ์๋๋๋ค.
๋ณธ ์ ํ์ ์ํ์ํ์ฑ์ ์๋ ํ์ฌ ์ค๋น๋์ด ์์ง ์์ต๋๋ค.
๋ถ์ ์ฐจํธ
๋กฏํธ ๋ฒํธ๋ฅผ ์
๋ ฅํ์ญ์์ค.
์๋ชป๋ ๋กํธ ๋ฒํธ๊ฐ ์
๋ ฅ๋์์ต๋๋ค.
์ฃ์กํฉ๋๋ค๋ง ์ฐพ์ผ์๋ ๋ถ์์ฐจํธ๋ ์์ต๋๋ค.