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CAS RN: 6533-68-2 | ์ ํ๋ฒํธ: S0021
Scopolamine Hydrobromide Trihydrate
×
์๋/๋ถ์ ๋ฐฉ๋ฒ: >98.0%(T)(HPLC)
๋์์ด์:
์ ํ๋ฌธ์:
| ํฌ์ฅ๋จ์ | ๊ฐ๊ฒฉ | ๋น์ผ์ถ๊ณ | 2-3์ผ ์ด๋ด ์ถ๊ณ | ์ถ๊ฐ๋ก ํ์ํ ๊ฒฝ์ฐ |
์ถํ ์ ๋ณด
|
|---|---|---|---|---|---|
| 1G |
โฉ197,000
|
≥40 | ≥100 | ์ฃผ๋ฌธ ํ 1์ฃผ ์ ๋ ์์๋ฉ๋๋ค | |
| 10G |
โฉ961,400
|
11 | 0 | ์ฃผ๋ฌธ ํ 2์ฃผ ์ ๋ ์์๋ฉ๋๋ค |
โข๋ณธ ์ ํ์ ์ฌ๊ณ ๋ ์ผ๋ณธ ๋ณธ์ฌ์ ์ฌ๊ณ ์
๋๋ค. ์ฃผ๋ฌธ์, 5์ผ์์ ์คํ์ค๊น์ง ๋์ฐฉ๋ฉ๋๋ค.
โข๋ณธ๊ฑด์ ์๊ฐ๊ฒฉ์ ํ๊ตญ ๋๋ฆฌ์ ์ ์์ ํ๋งค๊ฐ๊ฒฉ์ ๋๋ค.์์ธํ ์ ๋ณด๊ฐ ํ์ํ์๋ฉด ์ฐ๋ฝํด ์ฃผ์ญ์์ค.( SEJIN CI Co., Ltd. (ํ๊ตญ์ด๋๋ฆฌ์ ) ์ ํ : 02-2655-2480 ์ด๋ฉ์ผ : sales@sejinci.co.kr)
โข๋ณด๊ด ์กฐ๊ฑด์ ์๊ณ ์์ด ๋ณ๊ฒฝ ๋ ์ ์์ต๋๋ค. ์ ํ ๋ณด๊ด ์กฐ๊ฑด์ ์ต์ ์๋ฃ๋ ํํ์ด์ง์ ๊ธฐ์ฌ๋์ด ์์ผ๋ ์ํด ๋ถํ๋๋ฆฝ๋๋ค.
โข๋ณธ๊ฑด์ ์๊ฐ๊ฒฉ์ ํ๊ตญ ๋๋ฆฌ์ ์ ์์ ํ๋งค๊ฐ๊ฒฉ์ ๋๋ค.์์ธํ ์ ๋ณด๊ฐ ํ์ํ์๋ฉด ์ฐ๋ฝํด ์ฃผ์ญ์์ค.( SEJIN CI Co., Ltd. (ํ๊ตญ์ด๋๋ฆฌ์ ) ์ ํ : 02-2655-2480 ์ด๋ฉ์ผ : sales@sejinci.co.kr)
โข๋ณด๊ด ์กฐ๊ฑด์ ์๊ณ ์์ด ๋ณ๊ฒฝ ๋ ์ ์์ต๋๋ค. ์ ํ ๋ณด๊ด ์กฐ๊ฑด์ ์ต์ ์๋ฃ๋ ํํ์ด์ง์ ๊ธฐ์ฌ๋์ด ์์ผ๋ ์ํด ๋ถํ๋๋ฆฝ๋๋ค.
| ์ ํ๋ฒํธ | S0021 |
Purity/Analysis Method 
|
>98.0%(T)(HPLC) |
| M.F. / M.W. | C__1__7H__2__1NO__4ยทHBrยท3H__2O = 438.32 |
| ๋ฌผ๋ฆฌ์ ์ํ (20 โ) | Solid |
| ๋ณด๊ด ์กฐ๊ฑด
|
Room Temperature (Recommended in a cool and dark place, <15ยฐC) |
| ํผํด์ผ ํ ์กฐ๊ฑด | Light Sensitive |
| ์ฉ๊ธฐ
|
1G-Glass Bottle with Plastic Insert (์ด๋ฏธ์ง ๋ณด๊ธฐ) |
| CAS RN | 6533-68-2 |
| ๊ด๋ จ CAS RN
|
114-49-8&51-34-3 |
| Reaxys-RN | 6100669 |
| PubChem Substance ID | 87575651 |
| Merck Index (14) | 8406 |
| MDL ๋ฒํธ | MFCD00012647 |
๊ท๊ฒฉํ
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 %(after drying) |
| Specific rotation [a]20/D | -24.0 to -27.0 deg(C=5, H2O)(after drying) |
| Solubility in Water | almost transparency |
| Drying loss | max. 13.0 % |
| NMR | confirm to structure |
๋ฌผ์ฑ์น(์ฐธ๊ณ ์น)
| mp | 195 ยฐC |
| ๋น์จ ๊ดํ ํ์ [ฮฑ]D | -25.5ยฐ (C=5,H2O) |
GHS
| ํฝํ ๊ทธ๋จ |
|
| ์ ํธ ์๋ | Warning |
| ์ํ๋ฌผ ๋ฐ ์ ํด ๋ฑ๋ก | H302 : Harmful if swallowed. |
| ์ฃผ์ ์ฌํญ | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
๋ฒ๊ท ์ ๋ณด
| RTECS # | YM4550000 |
์ด์ก ์ ๋ณด
| UN ๋ฒํธ | UN1544 |
| ๋ฑ๊ธ | 6.1 |
| ํฌ์ฅ ๊ทธ๋ฃน | III |
| HS ๋ฒํธ* | 2939.79-000 |
Application
Scopolamine Hydrobromide: A Belladonna Alkaloid with Anticholinergic Activity
Scopolamine salts ([S0021][ S0230] and [S0231]) and N-oxide [S0229], belladonna alkaloids, are anticholinergic agents. Their free base, scopolamine competitively inhibits muscarinic receptors of the parasympathetic nervous system for acetylcholine and act as a nonselective muscarinic antagonist, producing peripheral anti-muscarinic, central sedative and antiemetic effects. The parasympatholytic scopolamine, structurally very similar to atropine [A0754] as well, is used in conditions requiring decreased parasympathetic activity. Therefore, scopolamine can inhibit the secretion of saliva and sweat, decrease gastrointestinal secretions and motility, and increase heart rate et al. (The product is for research purpose only.)
References
- The validity of scopolamine as a pharmacological model for cognitive impairment: A review of animal behavioral studies (a review)
- Analytical profile of scopolamine hydrobromide (a review on description, synthesis, physical properties, analytical stability and storage, pharmacology, and pharmacokinetics)
- HPLC determination of atropine sulfate and scopolamine hydrobromide in pharmaceuticals
- Fatal Datura poisoning: identification of atropine and scopolamine by high performance liquid chromatography/photodiode array/mass spectrometry
Application
Reagent for experimental amnesia (Alzheimer's disease) model
References
- Ameliorative effects of azaindolizinone derivative ZSET845 on scopolamine-induced deficits in passive avoidance and radial-arm maze learning in the rat
- Scopolamine as an antidepressant: a systematic review
- Antidepressant effects of the muscarinic cholinergic receptor antagonist scopolamine: a review
PubMed Literature
๋ฌธ์
์ ํ๊ธฐ์ฌ
์ ํ๋ฌธ์ (๋ถ์ ์ฐจํธ๋ฅผ ์ ๊ณตํ์ง ๋ชปํ ์๋ ์์ผ๋ ์ํด ๋ฐ๋๋๋ค.)
SDS
์ธ์ด๋ฅผ ์ ํํ์ญ์์ค.
์์ฒญํ SDS๋ฅผ ์ฌ์ฉํ ์ ์์ต๋๋ค.
๋ฒ๊ฑฐ๋กญ๊ฒ ํด๋๋ ค ์ฃ์กํ์ง๋ง ์ด ์์ ๋ณด๋ค ๋ฌธ์ ํด์ฃผ์ญ์์ค.
๊ท๊ฒฉํ
์ํ์ฑ์ ์๏ผ ๊ฐ์ข ์ฆ๋ช ์
๋กฏํธ ๋ฒํธ๋ฅผ ์
๋ ฅํ์ญ์์ค.
์๋ชป๋ ๋กํธ ๋ฒํธ๊ฐ ์
๋ ฅ๋์์ต๋๋ค.
์ํ ์ํ์ฑ์ ์
์ํ์ฑ์ ์ ์ํ์ ๋ค์ด๋ก๋ํ ์ ์์ต๋๋ค. ์ํ์ ๋ฐ๋์ ์ต์ ๋กํธ์ ๊ฒฐ๊ณผ๋ฅผ ๋ํ๋ด๋ ๊ฒ์ ์๋๋๋ค.
๋ณธ ์ ํ์ ์ํ์ํ์ฑ์ ์๋ ํ์ฌ ์ค๋น๋์ด ์์ง ์์ต๋๋ค.
๋ถ์ ์ฐจํธ
๋กฏํธ ๋ฒํธ๋ฅผ ์
๋ ฅํ์ญ์์ค.
์๋ชป๋ ๋กํธ ๋ฒํธ๊ฐ ์
๋ ฅ๋์์ต๋๋ค.
์ฃ์กํฉ๋๋ค๋ง ์ฐพ์ผ์๋ ๋ถ์์ฐจํธ๋ ์์ต๋๋ค.