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Pauson-Khand Reaction

The Pauson-Khand reaction is a [2+2+1] type cyclization reaction used to construct cyclopentenone moiety from alkynes and alkenes, mediated by dicobalt octacarbonyl. Alkynes have high affinity towards dicobalt octacarbonyl and form an alkyne-dicobalt intermediate which can be isolated. This intermediate then coordinates with an alkene followed by CO insertion to afford the cyclic product. In many cases, the Pauson-Khand reaction is utilized in the total synthesis of natural products bearing a cyclopentanone moiety.
Reagents:
Co2(CO)8
Reactants:
Alkynes, Alkenes
Products:
Cyclopentenones
Scheme:

Pauson-Khand_Reaction

Original literature:
Review literature: