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Versatile Reagent for Sulfoximidation

Dimethylsulfoximine (1) is a building block for the synthesis of sulfoximines and utilized in various types of sulfoximidation reactions. The installing method includes such as SN2 reaction,1) nucleophilic attack for carbonyl groups1,4) and cross-coupling reactions,2,3) and result the target compounds in high yields in each conditions. Furthermore, this functional group can be installed in the late stage of the synthesis during the C-H activation reaction.5) It is further anticipated that 1 can be used in medicinal chemistry and development of agrochemicals because of its abundant variation of reaction styles.

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