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Base-modified Ribonucleoside Triphosphates for mRNA Drug Discovery

RNA base-modified ribonucleoside triphosphate is used in in vitro transcription (IVT) of RNA medicines. RNA vaccines work by inducing the body to express viral proteins, which in turn stimulate the immune system to produce antibodies. In this process, the mRNA's own evasion of the immune system is important, along with the mRNA's translational efficiency. It is known that swapping nucleotides for a related analogue helped to make the mRNA less conspicuous to the immune system.1)
TCI has commercialized N1-methyl pseudouridine 5'-triphosphate sodium salt (Product No. M3544), pseudouridine 5'-triphosphate sodium salt (Product No. P3045), 5-methyluridine 5'-triphosphate sodium salt (Product No. M3582), 5-methylcytidine 5'-triphosphate sodium salt (Product No. M3583), 5-methoxyuridine 5'-triphosphate sodium salt (Product No. M3584) which are expected to have high translational efficiency and immunogenicity reduction effects, as raw materials for the synthesis of modified RNA medicines.2-6) These products have been checked for DNase and RNase contamination and functionality in IVT.

In recent years, studies in this field have been very active, new effects of base-modified nucleotides are continuously being reported. TCI is capable of performing the full process from modification of bases to triphosphorylation in-house, and can also provide base-modified triphosphates that are not listed in our catalog. TCI are also available for consultation on scale-up manufacturing.


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