Non-Detergents Sulfobetaines (NDSB)

Non-detergent sulfobetaines (NDSB) are amphiphilic small compounds containing both a cationic and anionic component which do not form micelles because of their small hydrophobic moiety. NDSBs solubilize proteins under mild conditions and can prevent protein denaturation by heat or acid, inhibit protein aggregation, acceleration protein refolding, and aid membrane protein extraction.