(-)-Epigallocatechin Gallate Hydrate

Reference

• 1) Flavonoids Enhance Lipofection Efficiency and Ameliorate Cytotoxicity in Colon26 and HepG2 Cells via Oxidative Stress Regulation
  • D. Hu, S. Fumoto, H. Miyamoto, M, Tanaka, K. Nishida, Pharmaceutics 2022, 14, 1203.


Anwendung
Gingipain inhibitor
Catechin derivatives, which included (-)-epigallocatechin gallate, (-)-epicatechin gallate, (-)-gallocatechin gallate, and (-)-catechin gallate, have been reported to inhibit Arg-gingipain (Rgp) in Porphyromonas gingivalis.¹⁾ The 50% inhibitory concentrations (IC₅₀s) of these catechin derivatives for Rgp ranged from 3 to 5 μM. (-)-Epigallocatechin gallate is one of these derivatives. The compound was also shown to inhibit Lys-gingipain (Kgp), although weaker than Rgp.²⁾
(The product is for research purpose only.)

Reference

• 1) Inhibitory effect of green tea catechins on cysteine proteinases in Porphyromonas gingivalis
  • M. Okamoto, A. Sugimoto, K.-P. Leung, K. Nakayama, A Kamaguchi, N. Maeda, Oral Microbiol. Immunol. 2004, 19, 118.
• 2) Inhibition of gingipains and Porphyromonas gingivalis growth and biofilm formation by prenyl flavonoids
  • T. Kariu, R. Nakao, T. Ikeda, K. Nakashima, J. Potempa, T. Imamura, J. Periodontal Res. 2017, 52, 89.


Anwendung
Efflux pump research
(-)-Epigallocatechin Gallate has been reported to inhibit efflux pump thereby enhancing the activity of tetracycline [T3971, T2525] in Staphylococci.¹⁾
(The product is for research purpose only.)

Reference

• 1) Epigallocatechin-Gallate Enhances the Activity of Tetracycline in Staphylococci by Inhibiting Its Efflux from Bacterial Cells
  • A. Sudano Roccaro, A.R. Blanco, F. Giuliano, D. Rusciano, V. Enea, Antimicrob. Agents Chemother. 2004, 48, 1968.


Anwendung
Type III secretion system (T3SS) research / Type III secretion system (T3SS) inhibitor

References

• Epigallocatechin gallate inhibits the type III secretion system of Gram-negative enteropathogenic bacteria under model conditions
  • N. Nakasone, N. Higa, C. Toma, Y. Ogura, T. Suzuki, T. Yamashiro, FEMS Microbiol. Lett. 2017, 364, fnx111.
• Epigallocatechin-3-gallate inhibits bacterial virulence and invasion of host cells
  • L.K. Tsou, J.S. Yount, H.C. Hang, Bioorg. Med. Chem. 2017, 25, 2883.


Anwendung
(-)-Epigallocatechin Gallate (EGCG): A Polyphenolic Compound with Diverse Biological Activities including Anti-Cancer Effects
(-)-Epigallocatechin gallate (EGCG), a polyphenolic compound, is the ester of epigallocatechin [E1084] and gallic acid [G0011]. EGCG has been found in a variety of plants including green and black tea plants, and reported to have diverse biological activities including antioxidant, anti-cancer, anti-angiogenic and cardiovascular protective effects. (The product is for research purpose only.)

References

• Tea catechins and polyphenols: health effects, metabolism, and antioxidant functions (a review)
  • J. V. Higdon, B. Frei, Crit. Rev. Food Sci. Nutr. 2003, 43, 89.
• Green tea catechin, epigallocatechin-3-gallate (EGCG): Mechanisms, perspectives and clinical applications (a review)
  • B. N. Singh, S. Shankar, R. K. Srivastava, Biochem. Pharmacol. 2011, 82, 1807.
• Green tea and its anti-angiogenesis effects (a review)
  • B. Rashidi, M. Malekzadeh, M. Goodarzi, A. Masoudifar, H. Mirzaei, Biomed. Pharmacother. 2017, 89, 949.
• Absorption, metabolism, anti-cancer effect and molecular targets of epigallocatechin gallate (EGCG): An updated review
  • R.-Y. Gan, H.-B. Li, Z.-Q. Sui, H. Corke, Crit. Rev. Food Sci. Nutr. 2018, 58, 924.
• Molecular understanding of Epigallocatechin gallate (EGCG) in cardiovascular and metabolic diseases (a review)
  • Q. Y. Eng, P. V. Thanikachalam, S. Ramamurthy, J. Ethnopharmacol. 2018, 210, 296.


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