Xanthane Hydride

References

• Nucleic acid therapeutics: basic concepts and recent developments
  • V. K. Sharma, P. Rungta, A. K. Prasad, RSC Adv. 2014, 4, 16618.
• 3H-1,2-Benzodithiol-3-one 1,1-dioxide
  • S. L. Beaucage, e-EROS Encycl. Reagents Org. Synth. 2012, 1.
• Phosphorothioate Oligonucleotides with Low Phosphate Diester Content:  Greater than 99.9% Sulfurization Efficiency with “Aged” Solutions of Phenylacetyl Disulfide (PADS)
  • A. H. Krotz, D. Gorman, P. Mataruse, C. Foster, J. D. Godbout, C. C. Coffin, A. N. Scozzari, Org. Proc. Res. Dev. 2004, 8, 852.
• Large-Scale Synthesis of Oligonucleotide Phosphorothioates Using 3-Amino-1,2,4-dithiazole-5-thione as an Efficient Sulfur-Transfer Reagent
  • J.-Y. Tang, Y. Han, J. X. Tang, Z. Zhang, Org. Proc. Res. Dev. 2000, 4, 194.
• Mechanism of the sulfurisation of phosphines and phosphites using 3-amino-1,2,4-dithiazole-5-thione (xanthane hydride)
  • J. Hanusek, M. A. Russell, A. P. Laws, P. Jansa, J. H. Atherton, K. Fettesd, M. I. Page, Org. Biomol. Chem. 2007, 5, 478.

References

• 1)Large-Scale Synthesis of Oligonucleotide Phosphorothioates Using 3-Amino-1,2,4-dithiazole-5-thione as an Efficient Sulfur-Transfer Reagent
  • J.-Y. Tang, Y. Han, J. X. Tang, Z. Zhang, Org. Proc. Res. Dev. 2000, 4, 194.
• 2)Mechanism of the sulfurisation of phosphines and phosphites using 3-amino-1,2,4-dithiazole-5-thione (xanthane hydride)
  • J. Hanusek, M. A. Russell, A. P. Laws, P. Jansa, J. H. Atherton, K. Fettesd, M. I. Page, Org. Biomol. Chem. 2007, 5, 478.
• 3)Evidence for the formation of isothiocyanate during sulfurisation of phosphines and phosphites using xanthane hydride
  • J. Hanusek, M. A. Russell, A. P. Laws, M. I. Page, Tetrahedron Lett. 2007, 48, 417.
• 4)Synthesis of 5’-GalNAc-Conjugated Oligonucleotides: A Comparison of Solid and Solution-Phase Conjugation Strategies
  • I. Cedillo, D. Chreng, E. Engle, L. Chen, A. K. McPherson, A. A. Rodriguez, Molecules 2017, 22, 1356.