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CAS RN: 878-23-9 | Product Number: B1036
2-Bromo-1-ethylpyridinium Tetrafluoroborate
Purity: >98.0%(T)(HPLC)
Synonyms:
Product Documents:
Size | Unit Price | Belgium | Japan* | Quantity |
---|---|---|---|---|
5G |
€63.00
|
1 | ≥100 |
|
25G |
€203.00
|
1 | ≥60 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
Product Number | B1036 |
Purity / Analysis Method | >98.0%(T)(HPLC) |
Molecular Formula / Molecular Weight | C__7H__9BBrF__4N = 273.86 |
Physical State (20 deg.C) | Solid |
Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
Store Under Inert Gas | Store under inert gas |
Condition to Avoid | Hygroscopic |
CAS RN | 878-23-9 |
Reaxys Registry Number | 4059265 |
PubChem Substance ID | 87563986 |
SDBS (AIST Spectral DB) | 4975 |
MDL Number | MFCD00060046 |
Specifications
Appearance | White to Almost white powder to crystal |
Purity(HPLC) | min. 98.0 area% |
Purity(Argentometric Titration) | min. 98.0 % |
Melting point | 103.0 to 106.0 °C |
Solubility in Water | very faint turbidity |
Properties (reference)
Melting Point | 103 °C |
Solubility in water | Soluble |
GHS
Pictogram | |
Signal Word | Danger |
Hazard Statements | H302 : Harmful if swallowed. H314 : Causes severe skin burns and eye damage. |
Precautionary Statements | P260 : Do not breathe dust. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P303 + P361 + P353 : IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water. P301 + P330 + P331 : IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor. P305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor. |
Related Laws:
EC Number | 212-900-2 |
Transport Information:
UN Number | UN1759 |
Class | 8 |
Packing Group | III |
HS Number | 2933399990 |
Application
Pyridinium Salt Effective for Condensations of N-Methyl Amino Acids
Experimental procedure3): To a solution of N-Boc-N-methyl-L-leucine methyl ester (3.00 g, 12.0 mmol) in CH2Cl2 (50 mL), trifluoroacetic acid (9.2 mL, 120 mmol) is added at -20 °C. The mixture is warmed up to rt and stirred for 2 h. The mixture is diluted with CH2Cl2 and neutralized carefully with sat. aq. NaHCO3. The aqueous layer is extracted with CH2Cl2 (2x) and the combined organic layers are dried over Na2SO4. After removal of the solvent in vacuo, the free amine is dissolved in dry CH2Cl2 (50 mL) and N-Cbz-(L)-valine (3.32 g, 13.2 mmol) and DIEA (4.1 mL, 24.0 mmol) are added. Then, BEP (3.61 g, 13.2 mmol) is added in small portions at rt, what resulted in a yellow colored solution. The mixture is stirred overnight, diluted with CH2Cl2 and washed with 1 mol/L aq. KHSO4, sat. aq. NaHCO3 and brine subsequently. The solvent is removed after drying (Na2SO4) and the residue is purified by column chromatography (silica, PE:EtOAc 8:2). The dipeptide 1 (4.08 g, 10.4 mmol, 87 %) is obtained as a colorless resin.
References
- 1)New Method for the Preparation of Carboxylic Esters
- 2)2-Bromo-1-ethyl Pyridinium Tetrafluoroborate (BEP): A Powerful Coupling Reagent for N-Methylated Peptide Synthesis
- 3)Total Synthesis of Cyclomarin A, a Marine Cycloheptapeptide with Anti-Tuberculosis and Anti-Malaria Activity
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