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CAS RN: 78351-75-4 | Product Number: C2884

1-(3-Chloroanilino)-4-phenylphthalazine


Purity: >98.0%(GC)
Synonyms:
  • MY-5445
  • 1-(3-Chlorophenyl)amino-4-phenylphthalazine
Documents:
20MG
65,00 €
1   ≥20 
100MG
225,00 €
1   ≥20 

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Product Number C2884
Purity / Analysis Method >98.0%(GC)
Molecular Formula / Molecular Weight C__2__0H__1__4ClN__3 = 331.8  
Physical State (20 deg.C) Solid
CAS RN 78351-75-4
PubChem Substance ID 253661527
MDL Number

MFCD00209838

Specifications
Appearance White to Almost white powder to crystal
Purity(GC) min. 98.0 %
Properties (reference)
GHS
Related Laws:
Transport Information:
HS Number 2933998090
Application
MY-5445: A Specific Inhibitor of Cyclic GMP Phosphodiesterase Type 5 (PDE5)

1-(3-Chloroanilino)-4-phenylphthalazine (MY-5445) is a specific inhibitor of cyclic GMP (cGMP) phosphodiesterase type 5 (PDE5). MY-5445 inhibits platelet aggregation by increasing cGMP content.

References

Effect of 1-(3-chloroanilino)-4-phenylphthalazine (MY-5445), a specific inhibitor of cyclic GMP phosphodiesterase, on human platelet aggregation

M. Hagiwara, T. Endo, T. Kanayama, H. Hidaka, J. Pharmacol. Exp. Ther. 1984, 228, 467.

Role of selective cyclic GMP phosphodiesterase inhibition in the myorelaxant actions of M&B 22,948, MY-5445, vinpocetine and 1-methyl-3-isobutyl-8-(methylamino)xanthine

J. E. Souness, R. Brazdil, B. K. Diocee, R. Jordan, Br. J. Pharmacol. 1989, 98, 725.

Exisulind induction of apoptosis involves guanosine 3',5'-cyclic monophosphate phosphodiesterase inhibition, protein kinase G activation, and attenuated β-catenin

W. J. Thompson, G. A. Piazza, H. Li, L. Liu, J. Fetter, B. Zhu, G. Sperl, D. Ahnen, R. Pamukcu, Cancer Res. 2000, 60, 3338.

Phosphodiesterase Type 5 Is Highly Expressed in the Hypertrophied Human Right Ventricle, and Acute Inhibition of Phosphodiesterase Type 5 Improves Contractility

J. Nagendran, S. L. Archer, D. Soliman, V. Gurtu, R. Moudgil, A. Haromy, C. St. Aubin, L. Webster, I. M. Rebeyka, D. B. Ross, P. E. Light, J. R. B. Dyck, E. D. Michelakis, Circulation 2007, 116, 238.


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