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CAS RN: 32986-56-4 | Product Number: T2503

Tobramycin


Purity: >94.0%(T)
Synonyms:
  • O-[3-Amino-3-deoxy-α-D-glucopyranosyl-(1→6)]-O-[2,6-diamino-2,3,6-trideoxy-α-D-ribo-hexopyranosyl-(1→4)]-2-deoxy-D-streptamine
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Product Number T2503
Purity / Analysis Method >94.0%(T)
Molecular Formula / Molecular Weight C__1__8H__3__7N__5O__9 = 467.52  
Physical State (20 deg.C) Solid
Store Under Inert Gas Store under inert gas
Condition to Avoid Hygroscopic
CAS RN 32986-56-4
Reaxys Registry Number 1357507
PubChem Substance ID 87560061
Merck Index (14) 9490
MDL Number

MFCD00077885

Specifications
Appearance White to Orange to Green powder to crystal
Purity(Nonaqueous Titration) min. 94.0 %(calcd.on anh.substance)
Specific rotation [a]20/D +138.0 to +148.0 deg(C=4, H2O)(calcd.on anh.substance)
Water max. 8.0 %
Properties (reference)
Melting Point 178 °C
Specific Rotation 143° (C=4,H2O)
Solubility in water Soluble
GHS
Related Laws:
EC Number 251-322-5
RTECS# WK2100000
Transport Information:
HS Number 2941900000
Application
Tobramycin: An Aminoglycoside Antibiotic Active Against Pseudomonas Aeruginosa

Tobramycin is an aminoglycoside antibiotic derived from Streptomyces tenebrarius, and is similar in structure to gentamicin [G0383]. Tobramycin interacts with the 30s and 50s subunit of prokaryotic ribosomes, and then it inhibits bacterial growth by inhibiting protein synthesis. Tobramycin is more active than gentamicin against Pseudomonas aeruginosa and active against many gentamicin resistant strains. Recently, inhaled tobramycin is effective in treating chronic Pseudomonas aeruginosa lung infection in cystic fibrosis. (The product is for research purpose only.)

References


PubMed Literature


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