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Published TCIMAIL newest issue No.201
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CAS RN: 6902-91-6 | Product Number: G0519
Germacrone
×
Purity: >98.0%(GC)
Synonyms:
- (E,E)-Germacra-3,7(11),9-trien-6-one
- trans,trans-3,7-Dimethyl-10-isopropylidene-3,7-cyclodecadien-1-one
- (3E,7E)-3,7-Dimethyl-10-(propan-2-ylidene)cyclodeca-3,7-dienone
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 20MG |
91,00 €
|
1 | 9 |
|
|
| 100MG |
291,00 €
|
1 | 2 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | G0519 |
Purity / Analysis Method 
|
>98.0%(GC) |
| Molecular Formula / Molecular Weight | C__1__5H__2__2O = 218.34 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container
|
20MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 6902-91-6 |
| Reaxys Registry Number | 2047453 |
| PubChem Substance ID | 354335190 |
| MDL Number | MFCD00210050 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 98.0 % |
| Melting point | 54.0 to 58.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 56 °C |
| Maximum Absorption Wavelength | 309 nm (MeOH) |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
| RTECS# | GU2210000 |
Transport Information:
| HS Number | 2914290090 |
Application
Germacrone: A Component in Curcumae Rhizoma with a Wide Range of Biological Activities
Germacrone is one of the main bioactive components in the traditional Chinese medicine Curcumae Rhizoma.1-3) It has been shown to possess a wide range of biological activities, such as antitumor, anti-inflammatory, immunomodulatory, and antivirus properties.4-7) In addition, syntheses of bioactive substances from germacrone have been reported.7,8) (The product is for research purpose only.)
References
- 1)Identification and quantitation of eleven sesquiterpenes in three species of Curcuma rhizomes by pressurized liquid extraction and gas chromatography-mass spectrometry
- 2)Preparative isolation and purification of germacrone and curdione from the essential oil of the rhizomes of Curcuma wenyujin by high-speed counter-current chromatography
- 3)Fast determination of curcumol, curdione and germacrone in three species of Curcuma rhizomes by microwave-assisted extraction followed by headspace solid-phase microextraction and gas chromatography-mass spectrometry
- 4)Germacrone inhibits the proliferation of breast cancer cell lines by inducing cell cycle arrest and promoting apoptosis
- 5)Anti-tumor effect of germacrone on human hepatoma cell lines through inducing G2/M cell cycle arrest and promoting apoptosis
- 6)Germacrone inhibits early stages of influenza virus infection
- 7)Germacrone: occurrence, synthesis, chemical transformations and biological properties (a review)
- 8)Efficient synthesis of the anticancer β-elemene and other bioactive elemanes from sustainable germacrone
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