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CAS RN: 532959-63-0 | Product Number: P3414
PF-4878691
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Purity: >95.0%(HPLC)(qNMR)
Synonyms:
- 852A
- N-[4-(4-Amino-2-ethyl-1H-imidazo[4,5-c]quinolin-1-yl)butyl]methanesulfonamide
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 25MG |
€ 187,00
|
Contact Us | ≥40 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | P3414 |
Purity / Analysis Method 
|
>95.0%(HPLC)(qNMR) |
| Molecular Formula / Molecular Weight | C__1__7H__2__3N__5O__2S = 361.46 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (<0°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Light Sensitive,Air Sensitive,Heat Sensitive |
| CAS RN | 532959-63-0 |
| Reaxys Registry Number | 11120614 |
| MDL Number | MFCD30533308 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(qNMR) | min. 95.0 % |
| Melting point | 206.0 to 210.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 208 °C |
GHS
Related Laws:
Transport Information:
| HS Number | 2935909099 |
Application
PF-4878691: An Agonist of Toll-Like Receptor 7 (TLR7)
PF-4878691 (a synonym: 852A) is a synthetic agonist of toll-like receptor 7 (TLR7), an innate immune receptor that detects single-stranded RNA (ssRNA) and plays an important role in infectious diseases. Its powerful immune-stimulatory action could potentially be used in anti-tumor therapy. (The product is for research use only.)
References
- First in Human Phase I Trial of 852A, a Novel Systemic Toll-like Receptor 7 Agonist, to Activate Innate Immune Responses in Patients with Advanced Cancer
- TLR7 Agonist 852A Inhibition of Tumor Cell Proliferation Is Dependent on Plasmacytoid Dendritic Cells and Type I IFN
- Anti-tumor activity of toll-like receptor 7 agonists (a review)
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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