Published TCIMAIL newest issue No.202
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Photolabile Protecting Groups
In the context of protecting groups, "caged" compounds refer to protecting groups bonded to bioactive molecules that can be readily removed in an orthogonal manner. The "caging" of bioactive molecule with photolabile protecting groups in particular have proven to be a particularly useful tool in biochemical research. Caged compounds in which bioactive substances are inactivated with photolabile protecting groups1) and can be activated by UV or visible light photoirradiation. Research towards controlling the topical expression of biomolecule activity using caged compounds has been recently reported and continues to be heavily investigated. To date, several classes of caged biomolecule have been synthesized and reported, including: nucleotides,1) amino acids,2) biotin,3) and sugars.4)
References
- 1) J. H. Kaplan, B. Forbush III, J. F. Hoffman, Biochemistry 1978, 17, 1929.
- 2) R. Wieboldt, K. R. Gee, L. Niu, D. Ramesh, B. K. Carpenter, G. P. Hess, P. Natl. Acad. Sci. USA 1994, 91, 8752.
- 3) T. Terai, E. Maki, S. Sugiyama, Y. Takahashi, H. Matsumura, Y. Mori, T. Nagano, Chem. Biol. 2011, 18, 1261.
- 4) C. Bier, D. Binder, D. Drobietz, A. Loeschcke, T. Drepper, K.-E. Jaeger, J. Pietruszka, Synthesis 2017, 49, 42.
| Product Number | A3678 |
| CAS RN | 188891-18-1 |
| Purity / Analysis Method: | >98.0%(HPLC)(qNMR) |
| Product Number | B5008 |
| CAS RN | 1256259-14-9 |
| Purity / Analysis Method: | >98.0%(T) |
| Product Number | B5738 |
| CAS RN | 223420-41-5 |
| Purity / Analysis Method: | >98.0%(T) |
![tert-Butyl 4-[4-(1-Hydroxyethyl)-2-methoxy-5-nitrophenoxy]butanoate](/medias/Tci-300-B6668.jpg?context=bWFzdGVyfHJvb3R8MTA1Mjd8aW1hZ2UvanBlZ3xhR1l6TDJobFl5ODVORGd3TVRnMU5UUTBOek0wTDFSamFTMHpNREJmUWpZMk5qZ3VhbkJufDY4YzQ3MjYyOWMyNmUxYmY4ZmY5NTk1ZjdhZDVlOThmNTIwYmMxZWVkNDAwMjk0MzQ3ZmJmYzI3ZDk2YmYyNzg "tert-Butyl 4-[4-(1-Hydroxyethyl)-2-methoxy-5-nitrophenoxy]butanoate")
| Product Number | B6668 |
| CAS RN | 1410809-16-3 |
| Purity / Analysis Method: | >98.0%(HPLC)(qNMR) |
| Product Number | B6669 |
| CAS RN | 1410809-15-2 |
| Purity / Analysis Method: | >98.0%(HPLC)(qNMR) |
| Product Number | D4970 |
| CAS RN | 54711-38-5 |
| Purity / Analysis Method: | >98.0%(GC) |
| Product Number | D5477 |
| CAS RN | 4101-32-0 |
| Purity / Analysis Method: | >98.0%(GC) |
| Product Number | N1069 |
| CAS RN | 159873-64-0 |
| Purity / Analysis Method: | >98.0%(GC) |
| Product Number | N1132 |
| CAS RN | 3205-25-2 |
| Purity / Analysis Method: | >98.0%(GC) |
| Product Number | N1133 |
| CAS RN | 64987-77-5 |
| Purity / Analysis Method: | >98.0%(GC) |
| Product Number | D6740 |
| CAS RN | 61986-72-9 |
| Purity / Analysis Method: | >95.0%(GC)(qNMR) |
New
| Product Number | D6857 |
| CAS RN | 54711-39-6 |
| Purity / Analysis Method: | >95.0%(GC)(qNMR) |
New
Product Number: A3678Purity / Analysis Method:
>98.0%(HPLC)(qNMR)
Product Number: B5008Purity / Analysis Method:
>98.0%(T)
Product Number: B5738Purity / Analysis Method:
>98.0%(T)
Product Number: B6668Purity / Analysis Method:
>98.0%(HPLC)(qNMR)
Product Number: B6669Purity / Analysis Method:
>98.0%(HPLC)(qNMR)
Product Number: D4970Purity / Analysis Method:
>98.0%(GC)
Product Number: D5477Purity / Analysis Method:
>98.0%(GC)
Product Number: N1069Purity / Analysis Method:
>98.0%(GC)
Product Number: N1132Purity / Analysis Method:
>98.0%(GC)
Product Number: N1133Purity / Analysis Method:
>98.0%(GC)
Product Number: D6740Purity / Analysis Method:
>95.0%(GC)(qNMR)| New
Product Number: D6857Purity / Analysis Method:
>95.0%(GC)(qNMR)| New
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