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Published TCIMAIL newest issue No.201
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CAS RN: 344423-98-9 | Product Number: A2476
Atorvastatin Calcium Salt Trihydrate
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Purity: >98.0%(HPLC)(N)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 1G |
€45.00
|
2 | ≥100 |
|
|
| 5G |
€158.00
|
2 | ≥100 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | A2476 |
Purity / Analysis Method 
|
>98.0%(HPLC)(N) |
| Molecular Formula / Molecular Weight | C__6__6H__6__8CaF__2N__4O__1__0·3H__2O = 1,209.41 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 344423-98-9 |
| Related CAS RN
|
134523-03-8&134523-00-5 |
| PubChem Substance ID | 135727313 |
| Merck Index (14) | 864 |
| MDL Number | MFCD09752074 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Specific rotation [a]20/D | -7.0 to -10.0 deg(C=1、DMSO)(calcd.on anh.substance) |
| Water | 3.5 to 5.5 % |
| NMR | confirm to structure |
Properties (reference)
| Specific Rotation | -8° (C=1,DMSO) |
| Solubility in water | Insoluble |
| Solubility (insoluble in) | Ethanol |
GHS
Related Laws:
Transport Information:
| HS Number | 2933998090 |
Application
Atorvastatin Calcium Salt: A Most Potent HMG-CoA Reductase Inhibitor
Enzyme HMG-CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase catalyzes the rate-limiting step in cholesterol biosynthesis. Statins inhibit the action of HMG-CoA reductase resulting in the reduction of low-density-lipoprotein (LDL) and total cholesterol levels. Especially in statins, atorvastatin calcium salt is a most potent statin because it has a long half-life and metabolites which also play a role as an HMG-CoA reductase inhibitor. Atorvastatin metabolized by cytochrome P450 3A4 (CYP3A4). In addition, we have a synthetic intermediate (atorvastatin acetonide tert-butyl ester [B3690]) for atorvastatin calcium salt. (The product is for research purpose only.)
References
- Structural mechanism for statin inhibition of HMG-CoA reductase
- The discovery and development of atorvastatin, a potent novel hypolipidemic agent (a review)
- HPLC methods for the determination of simvastatin and atorvastatin
- Atorvastatin calcium (a review on preparation, physical characteristics, methods of analysis, stability, metabolism, and pharmacokinetics of atorvastatin calcium)
PubMed Literature
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