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Published TCIMAIL newest issue No.201
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CAS RN: 304-20-1 | Product Number: H0409
1-Hydrazinophthalazine Hydrochloride
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Purity: >99.0%(T)(HPLC)
Synonyms:
- Hydralazine Hydrochloride
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 5G |
€ 35,00
|
3 | 9 |
|
|
| 25G |
€ 136,00
|
1 | 5 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | H0409 |
Purity / Analysis Method 
|
>99.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__8H__8N__4·HCl = 196.64 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 304-20-1 |
| Related CAS RN
|
86-54-4 |
| Reaxys Registry Number | 3568329 |
| PubChem Substance ID | 87570812 |
| Merck Index (14) | 4763 |
| MDL Number | MFCD00135998 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 99.0 area% |
| Purity( Potassium iodate Method) | min. 99.0 % |
| Solubility in Water | almost transparency |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 273 °C(dec.) |
| Solubility in water | Soluble |
| Degree of solubility in water | 44.2 g/l 25 °C |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. H361 : Suspected of damaging fertility or the unborn child. H362 : May cause harm to breast-fed children. |
| Precautionary Statements | P263 : Avoid contact during pregnancy and while nursing. P260 : Do not breathe dust. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. |
Related Laws:
| EC Number | 206-151-0 |
| RTECS# | TH9000000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
| HS Number | 2933998090 |
Application
Hydralazine Hydrochloride: A Vasodilator in Arterioles
Although the precise mechanism of action is not fully under-stood, hydralazine hydrochloride exerts its peripheral vasodilating effect through a direct relaxation of smooth muscle tissue in vascular resistance vessels, predominantly in the arterioles, and resulting in decreased blood pressure. Recently, the property of hydralazine has been reported, such as a DNA methylation inhibitor, an antioxidant and etc. (The product is for research purpose only.)
References
- Hydralazine and isosorbide dinitrate in heart failure: historical perspective, mechanisms, and future directions (a review)
- Hydralazine and procainamide inhibit T cell DNA methylation and induce autoreactivity
- Molecular Modeling and Molecular Dynamics Studies of Hydralazine with Human DNA Methyltransferase 1
- Hydralazine prevents nitroglycerin tolerance by inhibiting activation of a membrane-bound NADH oxidase. A new action for an old drug
- Hydralazine hydrochloride (a review including physical properties, synthesis, stability, metabolism and methods of analyzing)
- Spectrophotometric determination of hydralazine using p-dimethylaminobenzaldehyde
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