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CAS RN: 210353-53-0 | Product Number: G0617
Gemifloxacin Mesylate
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Purity: >95.0%(HPLC)(qNMR)
Synonyms:
- 7-[(4Z)-3-(Aminomethyl)-4-(methoxyimino)-1-pyrrolidinyl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic Acid Methanesulfonate
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 10MG |
€ 95,00
|
Contact Us | 28 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | G0617 |
Purity / Analysis Method 
|
>95.0%(HPLC)(qNMR) |
| Molecular Formula / Molecular Weight | C__1__8H__2__0FN__5O__4·CH__4O__3S = 485.49 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 210353-53-0 |
| Reaxys Registry Number | 8887755 |
| MDL Number | MFCD08277637 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(qNMR) | min. 95.0 % |
| NMR | confirm to structure |
Properties (reference)
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H317 : May cause an allergic skin reaction. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P272 : Contaminated work clothing should not be allowed out of the workplace. P280 : Wear protective gloves. P362 + P364 : Take off contaminated clothing and wash it before reuse. P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention. |
Related Laws:
| RTECS# | QN2790988 |
Transport Information:
| HS Number | 2933998090 |
Application
Gemifloxacin Mesylate: An Orally Active Broad-Spectrum Respiratory Quinolone Antibiotic
Gemifloxacin mesylate (LB20304) is an orally active broad-spectrum fluoroquinolone antibiotic. Fluoroquinolones, including gemifloxacin, inhibit DNA synthesis by inhibiting DNA gyrase and topoisomerase IV activities.1-3) The newest fluoroquinolones, such as gemifloxacin, gatifloxacin [G0627] and moxifloxacin [M2479], are known to have excellent in vitro activity against a wide range of respiratory pathogens and many aerobic Gram-negative organisms.3) (The product is for research purpose only.)
References
- 1) Novel Fluoroquinolone Antibacterial Agents Containing Oxime-Substituted (Aminomethyl)pyrrolidines: Synthesis and Antibacterial Activity of 7-(4-(Aminomethyl)-3-(methoxyimino)pyrrolidin-1-yl)-1-cyclopropyl -6-fluoro- 4-oxo-1,4-dihydro[1,8]naphthyridine-3-carboxylic Acid (LB20304)
- 2) Gemifloxacin (a review)
- 3) Gatifloxacin, gemifloxacin, and moxifloxacin: the role of 3 newer fluoroquinolones (a review)
- 4) Reverse phase-HPLC and HPTLC methods for determination of gemifloxacin mesylate in human plasma
- 5) Determination of gemifloxacin in different tissues of rat after oral dosing of gemifloxacin mesylate by LC-MS/MS and its application in drug tissue distribution study
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