Honokiol

Reference

• Honokiol induces paraptosis‑like cell death of acute promyelocytic leukemia via mTOR & MAPK signaling pathways activation
  • X. Liu, Y. Gu, Y. Bian, D. Cai, Y. Li, Y. Zhao, Z. Zhang, M. Xue, L. Zhang, Apoptosis 2021, 26, 195.


Application
Honokiol: A Natural Bioactive Neolignan Biphenol with Anti-Tumor Property etc.
Honokiol is a natural bioactive biphenyl-type neolignan isolated from the genus Magnolia. In recent studies, honokiol has been observed to have anti-angiogenic, anti-tumor, anti-inflammatory, anti-microbial and anti-oxidative properties in vitro and in vivo. Honokiol targets multiple signaling pathways including NF-κB, STAT3, EGFR, mTOR and caspase-mediated common pathway, which regulate cancer initiation and progression. For your reference, the chemical synthesis of honokiol has also been reported, and [T3468] is a synthetic intermediate. (The product is for research purpose only.)

References

• Honokiol, a Small Molecular Weight Natural Product, Inhibits Angiogenesis in Vitro and Tumor Growth in Vivo
  • X. Bai, F. Cerimele, M. Ushio-Fukai, M. Waqas, P. M. Campbell, B. Govindarajan, C. J. Der, T. Battle, D. A. Frank, K. Ye, E. Murad, W. Dubiel, G. Soff, J. L. Arbiser, J. Biol. Chem. 2003, 278, 35501.
• In vitro antibacterial and anti-inflammatory effects of honokiol and magnolol against Propionibacterium sp.
  • J. Park, J. Lee, E. Jung, Y. Park, K. Kim, B. Park, K. Jung, E. Park, J. Kim, D. Park, Eur. J. Pharmacol. 2004, 496, 189.
• Magnolol and honokiol isolated from Magnolia officinalis protect rat heart mitochondria against lipid peroxidation
  • Y.-C. Lo, T. Che-Ming, C. Chieh-Fu, C. Chien-Chih, H. Chuang-Ye, Biochem. Pharmacol. 1994, 47, 549.
• Honokiol, a Multifunctional Antiangiogenic and Antitumor Agent (a review)
  • L. E. Fried, J. L. Arbiser, Antioxid. Redox Signaling 2009, 11, 1139.
• Honokiol and magnolol as multifunctional antioxidative molecules for dermatologic disorders (a review)
  • J.-L. Shen, K.-M. Man, P.-H. Huang, W.-C. Chen, D.-C. Chen, Y.-W. Cheng, P.-L. Liu, M.-C. Chou, Y.-H. Chen, Molecules 2010, 15, 6452.
• Honokiol: a novel natural agent for cancer prevention and therapy (a review)
  • S. Arora, S. Singh, G. A. Piazza, C. M. Contreras, J. Panyam , A. P. Singh, Curr. Mol. Med. 2012, 12, 1244.


PubMed Literature