Published TCIMAIL newest issue No.199
Maximum quantity allowed is 999
Please select the quantity
CAS RN: 1217503-60-0 | Product Number: H1525
(1E,4E)-1-(4-Hydroxy-3,5-dimethoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1,4-pentadiene-3-one
×
![]()
×
Purity: >95.0%(HPLC)
Synonyms:
- GO-Y078
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 20MG |
69,00 €
|
Contact Us | 11 |
|
|
| 100MG |
219,00 €
|
Contact Us | 11 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | H1525 |
Purity / Analysis Method 
|
>95.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__2H__2__4O__7 = 400.43 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 1217503-60-0 |
| Reaxys Registry Number | 20091460 |
| PubChem Substance ID | 354333647 |
Specifications
| Appearance | White to Yellow to Orange powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
Properties (reference)
GHS
Related Laws:
| EC Number | 274-722-1 |
Transport Information:
| HS Number | 2914500090 |
Application
GO-Y078: A New Curcumin Analogue with Enhanced Antitumor Activities
Curcumin [C0434][C2302] has chemopreventive and chemotherapeutic potentials against various types of cancers, but low bioavailability prevents its use in chemotherapeutic applications. GO-Y078 and GO-Y030 [B4823] are new synthetic analogues of curcumin, developed by Shibata, Iwabuchi et al. to increase its potential and circumvent its low bioavailability.1,2) In their reports, GO-Y078 and GO-Y030 suppress the growth of myeloma cells, and are 7 to 12 times more effective than curcumin. GO-Y078 and GO-Y030 are also 6- to 15-fold stronger multi-target inhibitors (eg. nuclear factor-κB (NFκB)) than curcumin. Furthermore, GO-Y078 inhibits tumor angiogenesis through actin disorganization.3) In addition, the water solubility of GO-Y078 (1.07 mg/L) is 2 times higher than that of curcumin (0.54 mg/L).4) (The product is for research purpose only.)
References
- 1)Structure-activity relationship of C5-curcuminoids and synthesis of their molecular probes thereof
- 2)Novel curcumin analogs, GO-Y030 and GO-Y078, are multi-targeted agents with enhanced abilities for multiple myeloma
- 3)A curcumin analog, GO-Y078, effectively inhibits angiogenesis through actin disorganization
- 4)Synthesis of 86 species of 1,5-diaryl-3-oxo-1,4-pentadienes analogs of curcumin can yield a good lead in vivo
PubMed Literature
Documents
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
Please select Language.
The requested SDS is not available.
Please Contact Us for more information.
Specifications
C of A & Other Certificates
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
Sample C of A
This is a sample C of A and may not represent a recently manufactured lot of the product.
A sample C of A for this product is not available at this time.
Analytical Charts
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
The requested analytical chart is not available. Sorry for the inconvenience.