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CAS RN: 404950-80-7 | Product Number: P3137
Panobinostat
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Purity: >93.0%(HPLC)
Synonyms:
- (2E)-N-Hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide
- (E)-N-Hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]acrylamide
- LBH 589
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 10MG |
€60.00
|
1 | 29 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | P3137 |
Purity / Analysis Method 
|
>93.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__1H__2__3N__3O__2 = 349.43 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 404950-80-7 |
| Reaxys Registry Number | 12257756 |
| MDL Number | MFCD09833242 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 93.0 area% |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 115 °C |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. H361 : Suspected of damaging fertility or the unborn child. H370 : Causes damage to organs. H372 : Causes damage to organs through prolonged or repeated exposure. H341 : Suspected of causing genetic defects. |
| Precautionary Statements | P260 : Do not breathe dust. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. |
Related Laws:
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
| HS Number | 2933998090 |
Application
Panobinostat (LBH589): A Histone Deacetylase (HDAC) Inhibitor
Histone deacetylases (HDACs) catalyze the removal of acetyl groups from the lysine residues of histones and some non-histone proteins and play important roles in maintaining chromatin structure and regulating gene expression, including tumor suppressor genes, and thus represent valid targets in the search for cancer therapeutics. Panobinostat (LBH589) has been reported to inhibit the enzymatic activity of HDACs implicated in cancer and has demonstrated potent anti-tumor activity. (The product is for research purpose only.)
References
- Development of the pan-DAC inhibitor panobinostat (LBH589): Successes and challenges (a review)
- Panobinostat Panobinostat (LBH589): a potent pan-deacetylase inhibitor with promising activity against hematologic and solid tumors (a review)
- Panobinostat: First Global Approval (a review)
- Histone deacetylase inhibitors as anticancer drugs (a review)
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