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CAS RN: 23680-84-4 | Product Number: A2151
4-Amino-2-chloro-6,7-dimethoxyquinazoline
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Purity: >98.0%(HPLC)(N)
Synonyms:
- 2-Chloro-6,7-dimethoxy-4-quinazolinamine
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 5G |
€45.00
|
1 | 16 |
|
| 25G |
€143.00
|
1 | 2 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | A2151 |
Purity / Analysis Method 
|
>98.0%(HPLC)(N) |
| Molecular Formula / Molecular Weight | C__1__0H__1__0ClN__3O__2 = 239.66 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 23680-84-4 |
| Reaxys Registry Number | 747463 |
| PubChem Substance ID | 87560582 |
| MDL Number | MFCD00051734 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 302 °C(dec.) |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
| EC Number | 245-821-7 |
Transport Information:
| HS Number | 2933998090 |
Application
A Synthetic Intermediate of α1-Adrenoceptor Antagonists
This product is used as a synthetic intermediate of α1-adrenoceptor antagonists such as doxazosin mesylate [D4126]1-3) and terazosin hydrochloride [T2751]4).
References
- 1) 2,4-Diamino-6,7-dimethoxyquinazolines. 1. 2-[4-(1,4-Benzodioxan-2-ylcarbonyl)piperazin-1-yl] derivatives as α1-adrenoceptor antagonists and antihypertensive agents
- S. F. Campbell, M. J. Davey, J. D. Hardstone, B. N. Lewis, M. J. Palmer, J. Med. Chem. 1987, 30, 49.
- 2) Practical chemical and enzymatic technologies for (S)-1,4-benzodioxan-2-carboxypiperizine intermediate in the synthesis of (S)-doxazosin mesylate
- 3) A reliable multigram synthesis of (±) doxazosin
- 4) 4-amino-2[4-[1-(benzyloxycarbonyl)-2(S)-[[(1,1-dimethylethyl)amino]carbonyl]-piperazinyl]-6,7-dimethoxyquinazoline (L-765,314): A potent and selective α1b adrenergic receptor antagonist
PubMed Literature
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