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Published TCIMAIL newest issue No.199
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CAS RN: 95167-41-2 | Product Number: D6368
DY 131
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Purity: >98.0%(HPLC)(qNMR)
Synonyms:
- GSK 9089
- N'-(4-(Diethylamino)benzylidene)-4-hydroxybenzohydrazide
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 50MG |
€100.00
|
Contact Us | 34 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | D6368 |
Purity / Analysis Method 
|
>98.0%(HPLC)(qNMR) |
| Molecular Formula / Molecular Weight | C__1__8H__2__1N__3O__2 = 311.39 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive |
| CAS RN | 95167-41-2 |
| Reaxys Registry Number | 2765110 |
| MDL Number | MFCD00715585 |
Specifications
| Appearance | Light yellow to Yellow to Orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(qNMR) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 236 °C |
GHS
Related Laws:
Transport Information:
| HS Number | 2928009090 |
Application
DY131: An Estrogen-Related Receptors Agonist and a Hedgehog Pathway Antagonist
DY131 is a potent and selective agonist of the estrogen-related receptors (ERRγ and ERRβ).1,2) ERRγ agonist, DY131, suppresses cancer growth and represses the expression of Wnt signaling genes.3) DY131 is also a small molecule inhibitor of Smoothened (Smo) with potential anticancer activity. Smo is a cell surface receptor that mediates sonic hedgehog (Shh) signaling to regulate gene expression through the GLI transcription factors. DY131 inhibits the activity of the Shh pathway and prevents tumor growth.4) (The product is for research use only.)
References
- 1) Identification and Structure−Activity Relationship of Phenolic Acyl Hydrazones as Selective Agonists for the Estrogen-Related Orphan Nuclear Receptors ERRβ and ERRγ
- 2) Identification of an agonist ligand for estrogen-related receptors ERRβ/γ
- 3) Estrogen-related receptor gamma functions as a tumor suppressor in gastric cancer
- 4) Selective Identification of Hedgehog Pathway Antagonists By Direct Analysis of Smoothened Ciliary Translocation
Product Documents (Note: Some products will not have analytical charts available.)
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