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Published TCIMAIL newest issue No.198
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CAS RN: 112809-51-5 | Product Number: L0248
Letrozole
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 1-Bis(4-cyanophenyl)methyl-1,2,4-triazole
- 4,4'-(1,2,4-Triazol-1-ylmethylene)dibenzonitrile
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
€102.00
|
Contact Us | ≥100 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | L0248 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__7H__1__1N__5 = 285.31 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 112809-51-5 |
| Reaxys Registry Number | 6813913 |
| PubChem Substance ID | 172089003 |
| Merck Index (14) | 5450 |
| MDL Number | MFCD00866241 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 183.0 to 187.0 °C |
Properties (reference)
| Melting Point | 185 °C |
| Solubility in water | Insoluble |
| Solubility (slightly sol. in) | Methanol |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H302 + H312 + H332 : Harmful if swallowed, in contact with skin or if inhaled. H315 : Causes skin irritation. H319 : Causes serious eye irritation. H360 : May damage fertility or the unborn child. H362 : May cause harm to breast-fed children. |
| Precautionary Statements | P263 : Avoid contact during pregnancy and while nursing. P260 : Do not breathe dust. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. |
Related Laws:
| RTECS# | DI4957000 |
Transport Information:
| HS Number | 2933998090 |
Application
Letrozole: A Nonsteroidal, Potent and Selective Aromatase Inhibitor
Letrozole (CGS 20267), exemestane [E0941] and anastrozole [A2370] are third generation, and potent and selective aromatase inhibitors. In postmenopausal women, estrogens are mainly derived from the action of the aromatase which is responsible enzyme for the aromatization of androgens ([A0845] and [T0027]) into estrogens ([E0026] and [E0025]) respectively in the periphery. The growth of the breast cancer is stimulated or maintained by estrogens. Letrozole, exemestane and anastrozole inhibit aromatase and estrogen synthesis, resulting in suppressing tumor growth. (The product is for research purpose only.)
References
- Highly selective inhibition of estrogen biosynthesis by CGS 20267 (Letrozole), a new non-steroidal aromatase inhibitor
- Letrozole is more effective neoadjuvant endocrine therapy than tamoxifen for ErbB-1- and/or ErbB-2-positive, estrogen receptor-positive primary breast cancer: evidence from a phase III randomized trial
- Letrozole Inhibits Tumor Proliferation More Effectively than Tamoxifen Independent of HER1/2 Expression Status
- Aromatase inhibitors in the treatment of breast cancer (a review)
- Letrozole: a review of its use in postmenopausal women with advanced breast cancer
- High-performance liquid chromatography of the aromatase inhibitor, letrozole, and its metabolite in biological fluids with automated liquid-solid extraction and fluorescence detection
PubMed Literature
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