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CAS RN: 182004-65-5 | Product Number: N0966
KB-R 7943
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Purity: >98.0%(HPLC)
Synonyms:
- 4-[(4-Nitrobenzyl)oxy]phenethyl Carbamimidothioate Methanesulfonate
- Carbamimidothioic Acid 4-[(4-Nitrobenzyl)oxy]phenethyl Ester Methanesulfonate
- S-[4-[(4-Nitrobenzyl)oxy]phenethyl]isothiourea Methanesulfonate
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 10MG |
68,00 €
|
2 | Contact Us |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | N0966 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__6H__1__7N__3O__3S·CH__4O__3S = 427.49 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 182004-65-5 |
| Reaxys Registry Number | 9099076 |
| PubChem Substance ID | 253662008 |
| MDL Number | MFCD00952138 |
Specifications
| Appearance | White to Yellow to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 9.50 to 10.30 % |
| NMR | confirm to structure |
Properties (reference)
GHS
Related Laws:
Transport Information:
| HS Number | 2930909599 |
Application
Na+/Ca2+交換機構 (NCX) の阻害剤
This compound (often called KB-R7943) is an inhibitor of the Na+/Ca2+ exchanger (NCX). The NCX system plays a pivotal role in regulating intracellular Ca2+ concentration in cardiomyocytes, neuronal cells, kidney and a variety of other cells. NCX system performs a particularly important function in regulating cardiac contractility and electric activity. KB-R9743 appears to exhibit selectivity for Ca2+-influx-mode NCX activity (reverse mode of NCX).
References
- A novel isothiourea derivative selectively inhibits the reverse mode of Na+/Ca2+ exchange in cells expressing NCX1
- Cardioprotective effects of KB-R7943: a novel inhibitor of the reverse mode of Na+/Ca2+ exchanger
- KB-R7943 block of Ca2+ influx via Na+/Ca2+ exchange does not alter twitches or glycoside inotropy but prevents Ca2+ overload in rat ventricular myocytes
- Cardiac Na+-Ca2+ exchange: Molecular and pharmacological aspects (a review)
- Na+/Ca2+ exchange as a drug target-insights from molecular pharmacology and genetic engineering (a review)
PubMed Literature
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