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Published TCIMAIL newest issue No.199
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CAS RN: 366-70-1 | Product Number: P2550
Procarbazine Hydrochloride
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Purity: >98.0%(T)(HPLC)
Synonyms:
- N-Isopropyl-4-[(2-methylhydrazino)methyl]benzamide Hydrochloride
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 100MG |
€30.00
|
Contact Us | 6 |
|
| 500MG |
€98.00
|
Contact Us | ≥40 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | P2550 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__2H__1__9N__3O·HCl = 257.76 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 366-70-1 |
| Related CAS RN
|
671-16-9 |
| Reaxys Registry Number | 4024454 |
| PubChem Substance ID | 354335018 |
| Merck Index (14) | 7758 |
| MDL Number | MFCD00072082 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Argentometric Titration) | min. 98.0 % |
Properties (reference)
| Melting Point | 226 °C |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H302 : Harmful if swallowed. H360 : May damage fertility or the unborn child. H341 : Suspected of causing genetic defects. H350 : May cause cancer. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. |
Related Laws:
| EC Number | 206-678-6 |
| RTECS# | XS4725000 |
Transport Information:
| HS Number | 2928009090 |
Application
Procarbazine: An Antitumor Alkylating Agent
Procarbazine is an antitumor alkylating agent that was first synthesized in the late 1950s. Reportedly, procarbazine may inhibit transmethylation of methyl groups of methionine into t-RNA, and the non-functioning t-RNA could cause the cessation of DNA, RNA, and protein synthesis.
In addition, procarbazine can also directly damage DNA through an alkylation reaction. Alkylating agents including procarbazine are known to be associated with production of reactive oxygen species (ROS) which may attack protein sulfhydryl groups contained in protein which is tightly bound to DNA. Procarbazine is not cross-resistant with other alkylating agents. Procarbazine has been used in the treatment of many cancers, but its main use is in the treatment of Hodgkin's disease and brain tumors, since it can cross the blood-brain barrier. (The product is for research purpose only.)
In addition, procarbazine can also directly damage DNA through an alkylation reaction. Alkylating agents including procarbazine are known to be associated with production of reactive oxygen species (ROS) which may attack protein sulfhydryl groups contained in protein which is tightly bound to DNA. Procarbazine is not cross-resistant with other alkylating agents. Procarbazine has been used in the treatment of many cancers, but its main use is in the treatment of Hodgkin's disease and brain tumors, since it can cross the blood-brain barrier. (The product is for research purpose only.)
References
- Reappraisal of the use of procarbazine in the treatment of lymphomas and brain tumors (a review)
- The emerging role of reactive oxygen species in cancer therapy (a review)
- Procarbazine - a traditional drug in the treatment of malignant gliomas (a review)
- Procarbazine hydrochloride (a review on the physical properties, synthesis, stability, metabolites, toxicity, and methods of analysis)
- Determination of procarbazine in human plasma by liquid chromatography with electrospray ionization mass spectrometry
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